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nature communications的八卦，YOUTUBE和Yahoo名人娛樂都在討論

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在nature communications這個產品中，有156篇Facebook貼文，粉絲數超過16萬的網紅中央研究院 Academia Sinica，也在其Facebook貼文中提到， #兇手不只一個 阿茲海默症惡化😰？中研院找到 #蛋白質幫兇！ 👵👴👵👴 #阿茲海默症 是最常見的 #老年失智症。過去，科學認為阿茲海默症起因於：🧠大腦中的2種蛋白質錯誤堆疊： 1⃣：蛋白質Aβ（Amyloid-β） 2⃣：Tau蛋白（Tau Protein） 最近，中研院基...
　同時也有3部Youtube影片，追蹤數超過160萬的網紅ブライトサイド | Bright Side Japan，也在其Youtube影片中提到，大半の人々は恐竜について何を知っているのでしょう？ 恐竜の中には凄く大きかったものがいたり、羽を持っていたものもいて、更に6,600万年前に絶滅してしまった、というようなことですよね？ では、ニワトリと同じくらいのサイズの恐竜の存在や、毛皮に覆われた恐竜がいたというのはどうでしょう？ そして、本当は...

nature communications 在 中央研究院 Academia Sinica Facebook 八卦

中央研究院 Academia Sinica By 中央研究院 Academia Sinica

2020-11-29 21:00:07 有 3,703 人按讚
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#兇手不只一個

阿茲海默症惡化😰？中研院找到 #蛋白質幫兇！

👵👴👵👴
　　
#阿茲海默症 是最常見的 #老年失智症。過去，科學認為阿茲海默症起因於：🧠大腦中的2種蛋白質錯誤堆疊：
　　
1⃣：蛋白質Aβ（Amyloid-β）
2⃣：Tau蛋白（Tau Protein）
　　　
最近，中研院基因體研究中心 #陳韻如研究團隊 證實，導致阿茲海默症病情惡化，還有另一個💢蛋白質幫凶：
　　
3⃣：蛋白質TDP-43
　　
👉本研究證實：大腦 #蛋白質TDP-43 錯誤表現後，會與 #Aβ 作用，產生更有毒的中間產物，造成阿茲海默症病情惡化！
　　
👩‍🔬陳韻如表示，「我們發現TDP-43在阿茲海默症裡扮演多重的角色：一方面會直接與Aβ反應誘發Aβ寡聚體形成，造成 #神經突觸功能障礙，以及記憶受損；另一方面TDP-43也會增加 #腦部發炎反應，讓患者對於空間的記憶能力降低。」
　　
🌎全球約5,000萬名失智症患者中，有將近六、七成都是阿茲海默症病人。發病後會 #記憶力下降、#喪失語言功能、#空間感退化 #常迷路，造成自己及親友的生活負擔。但目前還沒有有效的治療藥物。
　　
📍本研究有助於掌握更多阿茲海默症的發病特徵及機制，未來，可望透過TDP-43，為神經退化疾病尋找🔍診斷及💊治療的新方法！
　　
📍本研究起始於兩位博士後研究學者施耀翔與杜玲嫻博士，並由張婷宇碩士加入團隊協力完成。研究成果已於今（2020）年11月23日發表於《#自然通訊》（Nature Communications）。

—
Curbing #TDP-43 May Ease the #Alzheimer’s Disease Progression
　　
Neurodegenerative diseases are making more impacts socially and economically as human life expectancy gets higher and higher. The scientific world still doesn’t have many clues regarding these diseases. Dr. Yun-Ru (Ruby) Chen’s research has been circled around the protein TDP-43 and its role in several neuro-degenerative diseases, in a paper published in the journal Nature Communications, they have reported a new insight into how TDP-43 is affecting Alzheimer’s disease.
　　
The team designed and made several antibodies, they will look into a solution in finding a best antibody that can do a preempt act to interact with TDP-43. If less inflammation can be managed, less memory loss of AD patients could be feasible. A synergistic effect to disrupt TDP-43 and Aβ interaction may also ameliorate AD.

—
📍新聞稿：https://www.sinica.edu.tw/ch/news/6721
📍Press Release: https://www.sinica.edu.tw/en/news/6721
📍論文全文：https://www.nature.com/articles/s41467-020-19786-7

—
#中研院基因體研究中心
#陳韻如副研究員
#神經退化疾病

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nature communications 在 唐家婕 - Jane Tang Facebook 八卦

唐家婕 - Jane Tang By 唐家婕 - Jane Tang

2021-01-06 07:32:58 有 2,091 人按讚
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Breaking‼️

美東時間1月5日傍晚，川普以國家安全為由，用行政命令方式禁止阿里支付寶、微信支付、QQ錢包在內的8款中國應用程式（App)。

行政命令發佈後45天，禁止任何人與實體與這8款中國應用程式（App）進行交易。

按照日程，美國下任政府將在15天後，1月20日上任。

—

美國商務部長在同一時間發聲明表示，已指示商務部按行政命令執行禁令，「支持川普總統保護美國人民隱私與安全，免於受到中國共產黨的威脅。」

—

▫️8款App:

支付寶（Alipay）、掃描全能王(CamScanner)、QQ錢包（QQ Wallet）、茄子快傳（SHAREit）、騰訊QQ（Tencent QQ）、阿里巴巴旗下海外短視頻應用VMate、微信支付（WeChat Pay）和辦公型App WPS Office。

圖三：美國商務部聲明

圖四：美國國安顧問聲明
—

▫️白宮行政命令全文：

The White House
Office of the Press Secretary
FOR IMMEDIATE RELEASE
January 5, 2021
EXECUTIVE ORDER



- - - - - - -



ADDRESSING THE THREAT POSED BY APPLICATIONS AND OTHER SOFTWARE DEVELOPED OR CONTROLLED BY CHINESE COMPANIES



By the authority vested in me as President by the Constitution and the laws of the United States of America, including the International Emergency Economic Powers Act (50 U.S.C. 1701 et seq.) (IEEPA), the National Emergencies Act (50 U.S.C. 1601 et seq.), and section 301 of title 3, United States Code,

I, DONALD J. TRUMP, President of the United States of America, find that additional steps must be taken to deal with the national emergency with respect to the information and communications technology and services supply chain declared in Executive Order 13873 of May 15, 2019 (Securing the Information and Communications Technology and Services Supply Chain). Specifically, the pace and pervasiveness of the spread in the United States of certain connected mobile and desktop applications and other software developed or controlled by persons in the People's Republic of China, to include Hong Kong and Macau (China), continue to threaten the national security, foreign policy, and economy of the United States. At this time, action must be taken to address the threat posed by these Chinese connected software applications.

By accessing personal electronic devices such as smartphones, tablets, and computers, Chinese connected software applications can access and capture vast swaths of information from users, including sensitive personally identifiable information and private information. This data collection threatens to provide the Government of the People's Republic of China (PRC) and the Chinese Communist Party (CCP) with access to Americans' personal and proprietary information -- which would permit China to track the locations of Federal employees and contractors, and build dossiers of personal information.

The continuing activity of the PRC and the CCP to steal or otherwise obtain United States persons' data makes clear that there is an intent to use bulk data collection to advance China's economic and national security agenda. For example, the 2014 cyber intrusions of the Office of Personnel Management of security clearance records of more than 21 million people were orchestrated by Chinese agents. In 2015, a Chinese hacking group breached the United States health insurance company Anthem, affecting more than 78 million Americans. And the Department of Justice indicted members of the Chinese military for the 2017 Equifax cyber intrusion that compromised the personal information of almost half of all Americans.

In light of these risks, many executive departments and agencies (agencies) have prohibited the use of Chinese connected software applications and other dangerous software on Federal Government computers and mobile phones. These prohibitions, however, are not enough given the nature of the threat from Chinese connected software applications. In fact, the Government of India has banned the use of more than 200 Chinese connected software applications throughout the country; in a statement, India's Ministry of Electronics and Information Technology asserted that the applications were "stealing and surreptitiously transmitting users' data in an unauthorized manner to servers which have locations outside India."

The United States has assessed that a number of Chinese connected software applications automatically capture vast swaths of information from millions of users in the United States, including sensitive personally identifiable information and private information, which would allow the PRC and CCP access to Americans' personal and proprietary information.

The United States must take aggressive action against those who develop or control Chinese connected software applications to protect our national security.

Accordingly, I hereby order:

Section 1. (a) The following actions shall be prohibited beginning 45 days after the date of this order, to the extent permitted under applicable law: any transaction by any person, or with respect to any property, subject to the jurisdiction of the United States, with persons that develop or control the following Chinese connected software applications, or with their subsidiaries, as those transactions and persons are identified by the Secretary of Commerce (Secretary) under subsection (e) of this section: Alipay, CamScanner, QQ Wallet, SHAREit, Tencent QQ, VMate, WeChat Pay, and WPS Office.

(b) The Secretary is directed to continue to evaluate Chinese connected software applications that may pose an unacceptable risk to the national security, foreign policy, or economy of the United States, and to take appropriate action in accordance with Executive Order 13873.

(c) Not later than 45 days after the date of this order, the Secretary, in consultation with the Attorney General and the Director of National Intelligence, shall provide a report to the Assistant to the President for National Security Affairs with recommendations to prevent the sale or transfer of United States user data to, or access of such data by, foreign adversaries, including through the establishment of regulations and policies to identify, control, and license the export of such data.

(d) The prohibitions in subsection (a) of this section apply except to the extent provided by statutes, or in regulations, orders, directives, or licenses that may be issued pursuant to this order, and notwithstanding any contract entered into or any license or permit granted before the date of this order.

(e) Not earlier than 45 days after the date of this order, the Secretary shall identify the transactions and persons that develop or control the Chinese connected software applications subject to subsection (a) of this section.

Sec. 2. (a) Any transaction by a United States person or within the United States that evades or avoids, has the purpose of evading or avoiding, causes a violation of, or attempts to violate the prohibition set forth in this order is prohibited.

(b) Any conspiracy formed to violate any of the prohibitions set forth in this order is prohibited.

Sec. 3. For the purposes of this order:

(a) the term "connected software application" means software, a software program, or group of software programs, designed to be used by an end user on an end-point computing device and designed to collect, process, or transmit data via the Internet as an integral part of its functionality.

(b) the term "entity" means a government or instrumentality of such government, partnership, association, trust, joint venture, corporation, group, subgroup, or other organization, including an international organization;

(c) the term "person" means an individual or entity;

(d) the term "personally identifiable information" (PII) is information that, when used alone or with other relevant data, can identify an individual. PII may contain direct identifiers (e.g., passport information) that can identify a person uniquely, or quasi-identifiers (e.g., race) that can be combined with other quasi-identifiers (e.g., date of birth) to successfully recognize an individual.

(e) the term "United States person" means any United States citizen, permanent resident alien, entity organized under the laws of the United States or any jurisdiction within the United States (including foreign branches), or any person in the United States.

Sec. 4. (a) The Secretary, in consultation with the Secretary of the Treasury and the Attorney General, is hereby authorized to take such actions, including adopting rules and regulations, and to employ all powers granted to me by IEEPA, as may be necessary to implement this order. All agencies shall take all appropriate measures within their authority to implement this order.

(b) The heads of agencies shall provide, in their discretion and to the extent permitted by law, such resources, information, and assistance to the Department of Commerce as required to implement this order, including the assignment of staff to the Department of Commerce to perform the duties described in this order.

Sec. 5. Severability. If any provision of this order, or the application of any provision to any person or circumstance, is held to be invalid, the remainder of this order and the application of its other provisions to any other persons or circumstances shall not be affected thereby.

Sec. 6. General Provisions. (a) Nothing in this order shall be construed to impair or otherwise affect:

(i) the authority granted by law to an executive department, agency, or the head thereof; or

(ii) the functions of the Director of the Office of Management and Budget relating to budgetary, administrative, or legislative proposals.

(b) This order shall be implemented consistent with applicable law and subject to the availability of appropriations.

(c) This order is not intended to, and does not, create any right or benefit, substantive or procedural, enforceable at law or in equity by any party against the United States, its departments, agencies, or entities, its officers, employees, or agents, or any other person.



DONALD J. TRUMP



THE WHITE HOUSE,

January 5, 2021.

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走闖華府的台灣記者，白宮記者。報導見於BBC,FT,財新,天下等。（引用請先?
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nature communications 在 中央研究院 Academia Sinica Facebook 八卦

中央研究院 Academia Sinica By 中央研究院 Academia Sinica

2020-01-22 18:45:29 有 1,443 人按讚
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全球首發！
　　
研究發現PS....PSPC1致癌基因的作用機制！
　　
#聞癌色變
#癌細胞擴散
　　
中研院生醫所周玉山研究員長期探索與癌細胞轉移有關的基因：PSPC1。近期，周玉山和藍耀東博士後研究員進一步發現其中致癌原理：PSPC1的異常表現將使細胞中的蛋白質「英雄變反派」，並產生癌細胞轉移等一系列致癌效果，更發展了可望抑制PSPC1的抑制劑。研究成果於2019年12月登上《自然通訊》（Nature Communications），也已申請多國專利，未來將有助於發展新穎的癌症治療藥物。
　　
周玉山強調，根據臨床數據統計，約有60~70%的癌症患者，其體內PSPC1基因都有大量表現。研究團隊從十年前發現並研究此一基因至今，終於近二年連續取得突破性進展。透過本次研究成果，我們未來可藉由檢測病患癌組織中「523號突變點」的表現程度，來預測腫瘤惡化的可能性。而「PSPC1抗癌抑制劑」則有對PSPC1及PTK6雙重抑制的效果，若可以用來控制腫瘤惡化與腫瘤轉移，將提升病患存活的機會，對癌症治療創造更具體的貢獻。
　　
👉新聞稿全文：https://www.sinica.edu.tw/ch/news/6473
　　
-\-\
In the latest study, postdoctoral researcher Dr. Yaw-dong Lang and the collaborators found that PSPC1 is the contextual determinant to determine the subcellular localizations of nucleocytoplasmic shuttling proteins such as non-receptor protein tyrosine kinase 6 (PTK6) and β-catenin related to their tumorigenicity in human hepatocellular carcinoma (HCC).
　　
👉Press release: https://www.sinica.edu.tw/en/news/6473
　　
媒體報導：
[中央社]中研院發現癌細胞轉移機制 可助新藥開發
https://www.cna.com.tw/news/ait/202001210114.aspx

[中國時報]中研院發現癌症轉移機制 有助開發新藥
https://www.chinatimes.com/realtimene…/20200121001758-260405

[自由時報]每個人都有這基因 中研院花十年找到實體癌症轉移關鍵
https://news.ltn.com.tw/news/life/breakingnews/3046576

[蘋果日報]癌轉移基因研究大突破 ！　中研院找到英雄變「反派」的關鍵酵素
https://tw.appledaily.com/…/202…/ZULYL6TNXVBVSS4PBY5K5HBTEU/

[公視]中研院發現加速癌症轉移之關鍵
https://www.youtube.com/watch?v=m4kL3ItUtG0

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這裡是由【中央研究院媒體小組】經營的平台，作為中研院好朋友們交流互動用，幾點注意事項還請粉絲們彼此提醒喲！ ＊發文請盡可能與學術研究、學術活動相關，勿濫用平台打廣告。 ＊有疑慮要發問，請保持基本禮貌，尊重自己也尊重別人。 ＊歡迎各種評論，但禁止謾罵或人身攻擊等，違者將隱藏、刪除貼文或封鎖帳號。 ＊有非關本文的意見，請善用「塗鴉牆」或「私訊」，發文下明顯不相干留言將隱藏或刪除，保持版面一致性。
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nature communications 在 ブライトサイド | Bright Side Japan Youtube 的評價

ブライトサイド | Bright Side Japan By ブライトサイド | Bright Side Japan

2019-04-13 09:30:00 有 220,222 人看過 有 1,887 人喜歡
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大半の人々は恐竜について何を知っているのでしょう？ 恐竜の中には凄く大きかったものがいたり、羽を持っていたものもいて、更に6,600万年前に絶滅してしまった、というようなことですよね？　では、ニワトリと同じくらいのサイズの恐竜の存在や、毛皮に覆われた恐竜がいたというのはどうでしょう？ そして、本当は絶滅していないというのは...？

タイムスタンプ:

ティラノサウルスは史上最大の恐竜とは程遠い大きさだった 0:36

恐竜は今までで最大の動物ではなかった 2:01

恐竜は本当は絶滅していない 3:00

恐竜は鱗ではなく羽毛で覆われていた 4:24

ジュラシックパークはいつの日か現実になり得る 5:50

最大の草食動物はそのサイズ同様の食いっぷりだった 7:11

ニワトリと同じくらいのサイズの恐竜が存在していた8:19

恐竜にはゴキブリ並みの大きさのノミがついていた 9:17

肉食恐竜はかなり大きな脳を持っていた 10:04

恐竜は脱皮していた 11:16

恐竜の中には毛皮で覆われていたものもいた 12:14



音楽：

エピデミックサウンド https://www.epidemicsound.com/



概要:

- 最大全長12 m、体重約9トンの、地上での恐竜の中でも最も大きいアルジェンティノサウルスと比べるとチビだったということになります。

- 今までに地球上に存在した最大の動物は恐竜である、と思い込んでいる人が多いと思いますが、実はそれは単なる勘違い。 実際、この惑星の歴史の中で最大の動物はシロナガスクジラ。

- カリフォルニア大学バークレー校の科学者によると、鳥は恐竜の遠い親戚ではなく、恐竜そのものだということ!

- 時間の経過とともに、より多くの化石が発見されるにつれ、古生物学者はティラノサウルスと、その同種を含む、ほとんどの恐竜が羽毛で覆われていたことを結論付けたのです。

- まだ孵化さえしていないヒヨコが、古代のトカゲに似た下肢を持って成長したのです。 純粋な科学的理論は別として、この実験は、鳥がいずれ実際に恐竜になり得るということを示しました。

- 史上最少の恐竜は、コンプソグナトゥスと呼ばれるもので、それはちょうどニワトリほどの大きさのものでした。

- 肉食恐竜は、はるかに大きな脳を持っていました。 ですので、この捕食動物の脳がクルミ程の大きさであるという描写は、事実に反しているということ。

- Nature Communications（ネイチャー　コミュニケーションズ）誌に掲載された2018年の研究によると、化石化した恐竜のフケは、この古代のトカゲが脱皮していた証拠になり得るということ！

- ブリストル大学の古生物学者は、翼竜の中には数種類の異なった体毛で覆われていた可能性があるものもいた、ということを示唆しました。 頭部と翼は羽毛で覆われていて、残りの部分は柔らかい毛皮で覆われていた可能性があるということなんです。

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nature communications 在 LDA World Youtube 的評價

LDA World By LDA World

2021-01-20 21:01:51 有 8,604 人看過 有 565 人喜歡
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ค้นพบแล้ว! รักษาผู้ป่วยอัมพาตให้เดินได้อีกครั้ง ด้วยการตัดแต่งพันธุกรรมโปรตีน
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ความหวังใหม่ของผู้ป่วยอัมพาต เมื่อนักวิทยาศาสตร์สามารถค้นพบวิธีรักษาให้กลับมาเดินได้อีกครั้ง หลังจากที่ก่อนหน้านี้ยังไม่สามารถหาวิธีรักษาอาการของผู้ป่วยได้
ออยมาเล่าให้ฟังไว ๆ ว่าพัฒนาการไปถึงไหน? รักษาจริงได้เมื่อไหร่? ทดลองสำเร็จหรือยัง ?

#FasterFuture #OilLDA #ตัดแต่งพันธุกรรมรักษาโรค
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About 'LDA: Ladies of Digital Age' สื่อและสังคมความรู้สำหรับคนยุคใหม่ ที่อยากใช้ชีวิตในโลกเทคโนโลยีอย่างมีความสุขและสนุกไปกับมัน เพราะเราเชื่อว่ายุคนี้ ความรู้ = โอกาส บอกเล่าผ่านผู้หญิง "กลุ่มคนธรรมดา" ที่อยากแบ่งปันความรู้ด้านเทคโนโลยีแบบเข้าใจง่าย ให้เข้าถึงได้สำหรับทุกคน ไม่ใช่ในฐานะกูรู แต่ในฐานะตัวแทนคนธรรมดา เพื่อให้ทุกคนพร้อมใช้ชีวิดในโลกอนาคตอย่างมีความสุข ? นำเสนอคอนเทนต์เกี่ยวกับ การเปลี่ยนแปลงของโลกในด้านเทคโนโลยี, Future Tech, การรับมือและใช้ชีวิตกับโลกที่หมุนอย่างรวดเร็ว, Smartphone, Gadget, Tips & Tricks ที่ทำให้ชีวิตง่ายขึ้น พวกเราเชื่อในความเท่าเทียม เชื่อว่าทุกคนมีศักยภาพที่สามารถทำอะไรก็ได้ ถ้ามี ""ความพยายาม"" มากพอ ไม่จำกัดแค่ผู้ชาย ผู้หญิง เด็ก หรือผู้ใหญ่ มาติดอาวุธความรู้ด้านเทคโนโลยีไปกับพวกเราได้ผ่านช่องทางเหล่านี้เลยค่า ? Facebook: http://facebook.com/ldaworld Blockdit: https://www.blockdit.com/ldaworld Blog: www.ldaworld.com Instagram: @Ldaworld TikTok: @ldaworld
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nature communications 在 Noodles with Turtle Youtube 的評價

Noodles with Turtle By Noodles with Turtle

2019-08-31 15:48:15 有 85 人看過 有 1 人喜歡
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7/17，Neuralink 舉辦了一場成果發佈兼招募會，在正式論文發布之前就搶先公佈目前在小鼠（以及猴子）身上進行的實驗成果與新技術，包括新的極細柔性導線、能夠自動將導線迅速插入大腦的神經外科機器人、以及一款新的 N1 晶片，用以讀取、清理與放大來自大腦的訊號。

無獨有偶地，在 7/30 ，Facebook 資助的美國加州大學舊金山分校研究團隊，也在《自然-通訊 (Nature Communications) 》期刊上發表了最新的研究成果。透過侵入式的腦機介面，科學家能夠根據大腦皮質的活動，「知道」實驗參與者針對問題回答了哪個選項，準確率比平均機率高出許多。

你或許知道 Neuralink 這家公司，它是由特斯拉跟 SpaceX 的老闆伊隆馬斯克，在 2016 年成立的公司，專攻腦機介面 (brain-computer interface) 。馬斯克聲稱他的目的是讓人類能夠以最快的速率來跟人工智慧溝通甚至更進一步與機器整合，以免落後太多給人工智慧，他認為這是讓人類免於人工智慧末日最好的預防方式。

然而這項技術接著會將我們帶到哪裡呢？

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