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在glp 1 ra這個產品中，有15篇Facebook貼文，粉絲數超過1萬的網紅劉漢文醫師，也在其Facebook貼文中提到， 2018 ADA/EASD 第二型糖尿病降血糖藥物總覽 http://hanwenliu.blogspot.com/2018/…/2018-ADA-EASD-T2DM.html 2018 年新版的美國糖尿病學會 (ADA)、歐洲糖尿病學會 (EASD) 第二型糖尿病高血糖控制共識報告，在...

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劉漢文醫師 By 劉漢文醫師

2018-10-06 01:28:17 有 648 人按讚
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2018 ADA/EASD 第二型糖尿病降血糖藥物總覽
http://hanwenliu.blogspot.com/2018/…/2018-ADA-EASD-T2DM.html
　
2018 年新版的美國糖尿病學會 (ADA)、歐洲糖尿病學會 (EASD) 第二型糖尿病高血糖控制共識報告，在 EASD 年會的最後一天發佈。跟 ADA 的治療指引一樣，都跟先前的版本有很大的不同。
　
多了好幾個流程圖，有心血管疾病/慢性腎臟病為考量、以體重為考量、以低血糖風險為考量、以藥價為考量。這篇只把總覽的大圖翻譯成中文。
　
圖中註解：
　
1. 心血管實證表示藥物可減少心血管事件。GLP-1 RA 證據最強為 liraglutide > semaglutide > 緩釋型 exenatide。SGLT2i 證據較強為 empagliflozin > canagliflozin。

2. 注意在不同地區及個別 SGLT2i 在起始和續用的 eGFR 範圍會不一樣。

3. Empagliflozin 和 canagliflozin 的心血管預後研究都顯示減少心衰竭和 CKD 進展。

4. Degludec 和 glargine U100 證明具心血管安全性。

5. 低劑量 TZD 可能耐受性較好，但就心血管益處的研究較少。

6. 選擇較新一代 SU，低血糖風險較小。

7. 基礎胰島素的低血糖風險：degludec/glargine U300 < glargine U100/detemir < NPH insulin。

8. GLP-1 RA 的減重效果：semaglutide > liraglutide > dulaglutide > exenatide > lixisenatide。

9. 以藥費為考量的前提，是沒有特定的共病症 (如: 沒有心血管疾病、低血糖風險小、較不擔心增加體重或沒有體重相關共病症)。

10. 要考量各國及各地區的藥價。在某些國家 TZD 相對較貴，DPP-4i 較便宜。
　
--
　
如果醫護同好有教學需求，歡迎下載大圖使用，不用問我。
　
細節還是要看原文喔！
http://care.diabetesjournals.org/…/ea…/2018/09/27/dci18-0033

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糖尿病、內分泌疾病、骨質疏鬆症的臨床經驗分享
糖尿病、內分泌疾病、骨質疏鬆症的臨床經驗分享。
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劉漢文醫師 By 劉漢文醫師

2018-10-05 08:00:00 有 646 人按讚
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2018 ADA/EASD 第二型糖尿病降血糖藥物總覽
http://hanwenliu.blogspot.com/2018/…/2018-ADA-EASD-T2DM.html
　
2018 年新版的美國糖尿病學會 (ADA)、歐洲糖尿病學會 (EASD) 第二型糖尿病高血糖控制共識報告，在 EASD 年會的最後一天發佈。跟 ADA 的治療指引一樣，都跟先前的版本有很大的不同。
　
多了好幾個流程圖，有心血管疾病/慢性腎臟病為考量、以體重為考量、以低血糖風險為考量、以藥價為考量。這篇只把總覽的大圖翻譯成中文。
　
圖中註解：
　
1. 心血管實證表示藥物可減少心血管事件。GLP-1 RA 證據最強為 liraglutide > semaglutide > 緩釋型 exenatide。SGLT2i 證據較強為 empagliflozin > canagliflozin。

2. 注意在不同地區及個別 SGLT2i 在起始和續用的 eGFR 範圍會不一樣。

3. Empagliflozin 和 canagliflozin 的心血管預後研究都顯示減少心衰竭和 CKD 進展。

4. Degludec 和 glargine U100 證明具心血管安全性。

5. 低劑量 TZD 可能耐受性較好，但就心血管益處的研究較少。

6. 選擇較新一代 SU，低血糖風險較小。

7. 基礎胰島素的低血糖風險：degludec/glargine U300 < glargine U100/detemir < NPH insulin。

8. GLP-1 RA 的減重效果：semaglutide > liraglutide > dulaglutide > exenatide > lixisenatide。

9. 以藥費為考量的前提，是沒有特定的共病症 (如: 沒有心血管疾病、低血糖風險小、較不擔心增加體重或沒有體重相關共病症)。

10. 要考量各國及各地區的藥價。在某些國家 TZD 相對較貴，DPP-4i 較便宜。
　
-\-\
　
如果醫護同好有教學需求，歡迎下載大圖使用，不用問我。
　
細節還是要看原文喔！
http://care.diabetesjournals.org/…/ea…/2018/09/27/dci18-0033

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劉漢文醫師

About author
糖尿病、內分泌疾病、骨質疏鬆症的臨床經驗分享
糖尿病、內分泌疾病、骨質疏鬆症的臨床經驗分享。
12948 followers 11370 likes "http://hanwenliu.blogspot.tw/"
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劉漢文醫師 By 劉漢文醫師

2019-09-02 08:00:00 有 607 人按讚
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歐洲心臟學會 (ESC) 與歐洲糖尿病研究學會 (EASD) 合作的 2019 糖尿病與心血管疾病治療指引
　
Metformin 作為第一線的血糖藥已經很久了。由於這幾年許多的糖尿病藥物心血管預後研究，顯示腸泌素 GLP-1 RA 藥物和排尿糖藥 SGLT-2 抑制劑可以減少心血管風險，ESC 和 EASD 的新版藥物流程圖把 GLP-1 RA 和 SGLT-2 抑制劑的位置放的更前面。
　
🔴 還未使用血糖藥的第二型糖尿病患者，如果有動脈硬化心血管疾病 (ASCVD) 或高/極高的心血管疾病風險 (包含標的器官損傷或多重危險因子)，直接使用有心血管實證的 SGLT-2 抑制劑或 GLP-1 RA。沒有 ASCVD 或中等以下的心血管風險，才是用 metformin。
　
-\-\
　
心血管疾病風險的分類
　
極高風險：
🔸 糖尿病且有心血管疾病、
🔸 或標的器官損傷 (蛋白尿、腎功能受損 eGFR 30 以下、左心室肥大、視網膜病變)、
🔸 或三個以上主要危險因子 (年齡、高血壓、血脂異常、抽菸、肥胖)、
🔸 或早發的第一型糖尿病 (超過 20 年病史)。
　
高風險：
🔸 糖尿病病史 10 年以上，沒有標的器官損傷，也沒有其他風險因子。
　
中等風險：
🔸 年輕的病人 (第一型年齡小於 35 歲、第二型年齡小於 50 歲) 病史小於 10 年，且沒有其他危險因子。

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糖尿病、內分泌疾病、骨質疏鬆症的臨床經驗分享
糖尿病、內分泌疾病、骨質疏鬆症的臨床經驗分享。
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#1. 第二型糖尿病新藥介紹作者：臺大醫院藥劑部陳建豪藥師專題 ...

當血糖上升時，GLP-1會促進胰島素分泌，使血中的葡萄糖進入肌肉與肝臟儲存；同時，GLP-1會抑制升糖素分泌，以減少肝臟繼續製造葡萄糖（圖二）。GLP-1可降低胃排空的速度， ...

#2. 1受體促效劑(GLP-1 Receptor Agonist) - 高雄醫師公會

GLP -1 RA是蛋白質的成份，不. 能口服，只能注射，一般是皮下注. 射，美國FDA（食物藥物管理局）在. 2005年通過Exenatide BID（短效型. 一天兩次），2010年通過. 非胰島素 ...

#3. GLP-1RA 之概述與臨床試驗結果

第一型類升糖素胜肽受體致效劑(Glucagon-like peptide-1 receptor agonist ( 以下簡. 稱GLP-1RA)) 是近年來新型的糖尿病藥物之一，其優點除了較不容易 ...

#4. GLP1受體促效劑類降血糖藥物介紹(一) - 糖尿病筆記

Glucagon-like peptide -1(GLP1)是腸泌素(Incretin)類荷爾蒙，由腸胃道的L細胞經食物刺激後所分泌。GLP1藉由以下幾個機制來達到降血糖的效果：刺激胰臟 ...

#5. 新藥介紹：Semaglutide (Ozempic ) - 國泰綜合醫院

進之GLP-1 RA-Semaglutide (Ozempic®. )。 二、成份. 本藥品為注射劑型，每1ml含有1.34mg. 主成分semaglutide，每支含有1.5 mL，總劑. 量2.01 mg。

#6. 關於GLP-1注射劑你該知道的事情 - 講糖

Glucagon-like peptide -1（GLP-1）是增泌素（Incretin）類荷爾蒙，由腸胃道細胞所分泌。(延伸閱讀：什麼是GLP-1 RA（類升糖素?-1受體促效劑）？)

#7. 治療糖尿病不麻煩一週注射一次的GLP-1 - 郭綜合醫院

易週糖含有dulaglutide，為一種人類GLP-1(glucagon-like peptide 1)受體促進劑，是一種30個胺基酸組成的胜肽，存在於末端迴腸和結腸中的L細胞中。進食時腸道所分泌的荷爾蒙 ...

#8. GLP-1 receptor agonists: an updated review of head-to-head ...

Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are attractive options for the treatment of type 2 diabetes (T2D) because they ...

#9. 糖尿病用藥GLP-1受體促效劑有口服劑型可降血糖

糖尿病用藥GLP-1受體促效劑是非胰島素的注射型降血糖藥物，是目前在糖尿病研究中最重要的腸道荷爾蒙。類升糖素胜肽-1（Glucagon-like peptide-1, ...

#10. GLP-1 receptor agonists and cardiorenal outcomes in type 2 ...

由 D Giugliano 著作 · 2021 · 被引用 11 次 — GLP-1RA have moderate benefits on MACE, and also reduce hospitalization for heart failure and all-cause mortality; they also have robust ...

#11. Glucagon-like peptide 1 receptor agonists for the treatment of ...

GLP -1 – The role of GLP-1 in glucose homeostasis is illustrative of the incretin effect, in which oral glucose has a greater stimulatory effect ...

#12. GLP-1 Receptor Agonists: Beyond Their Pancreatic Effects

Glucagon like peptide -1 receptor (GLP-1R) is a member of the B family of G protein-coupled receptors. In the pancreas, the interaction of GLP-1 ...

#13. GLP-1 Receptor Agonists for Type 2 Diabetes - Healthline

Glucagon-like peptide -1 receptor agonists (GLP-1 RAs) are a class of medications used to treat type 2 diabetes. Learn about the different ...

#14. Racial, Ethnic, and Socioeconomic Inequities in Glucagon ...

Key Points. Question Are there inequities in glucagon-like peptide-1 receptor agonist (GLP-1 RA) use based on race, ethnicity, sex, ...

#15. 胰高血糖素樣肽-1類似物- 維基百科

GLP -1類似物結構與人天然GLP-1結構類似，但生理功能相同，可以調節葡萄糖分泌。 發現歷史及治療潛力[編輯]. 20世紀80年代，根據生理學研究，口服葡萄糖與靜脈輸注相比 ...

#16. GLP-1 receptor agonists in the treatment of type 2 diabetes

The combination of (basal) insulin with a GLP-1 RA is a highly effective treatment even for advanced stages of type 2 diabetes. It should only be used in ...

#17. Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure

First-line treatment of T2DM in HF should include metformin and SGLT-2i. GLP-1 RA may be considered in patients with T2DM and HF. American ...

#18. 糖尿病藥物治療新方向 - 亞東醫院

昇糖素類似胜?(Glucagon-Like Peptide 1，GLP-1)是人體內最主要的腸泌素，是由遠端迴腸及部分大腸所分泌的腸道荷爾蒙，食物會刺激GLP-1由腸道分泌，依據血中葡萄糖濃度的 ...

#19. GLP-1 agonists: Diabetes drugs and weight loss - Mayo Clinic

There's a class of type 2 diabetes drugs that not only improves blood sugar control but may also lead to weight loss. This class of drugs is commonly called ...

#20. GLP-1 RA & CVD - PACE-CME

GLP -1 RA & CVD. Follow news, literature and expert opinions on GLP-1 as emerging target in the management of T2DM & Cardiovascular Disease ...

#21. View of Glucagon like peptide-1 receptor agonist (GLP-1RA ...

Glucagon like peptide -1 receptor agonists (GLP-1RAs) are a new class of injectable agent used in the management of type 2 diabetes (T2DM). ... Unlike many other ...

#22. What is GLP-1 and how does it work - Diabetes What's Next

GLP -1 RA is a class of non-insulin medication that assists your body's natural ability to regulate blood sugar and appetite 2. GLP-1 RA can help reduce the risk ...

#23. GLP-1 receptor agonists | Diabetes - type 2 | CKS

Standard-release formulation: 5 micrograms twice daily, increased if necessary, after at least 1 month to a maximum dose of 10 micrograms twice daily. It should ...

#24. A meta-analysis of the effects of glucagon-like-peptide 1 ...

A meta-analysis of the effects of glucagon-like-peptide 1 receptor agonist (GLP1-RA) in nonalcoholic fatty liver disease (NAFLD) with type 2 ...

#25. An overview of GLP-1 agonists and recent cardiovascular ...

To date, there have been seven GLP-1 RA CVOTs as previously outlined. Of these, all have shown non-inferiority, and liraglutide, subcutaneous semaglutide, ...

#26. Classification of currently available glucagon-like peptide-1 ...

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are one such class of antidiabetes therapies, wherein multiple GLP-1RA CVOTs, but interestingly, not all, ...

#27. GLP-1 Agonists - Prices and Information - GoodRx

GLP -1 agonists are used to lower blood sugar levels to treat diabetes type 2 by releasing more insulin into the bloodstream. Why are GLP-1 Agonists prescribed?

#28. Glucagon-like peptide-1 receptor agonists (GLP-1 RA) as ...

We aimed to determine the effectiveness of GLP-1 RA as adjunct to standard treatment among diabetic patients with chronic heart failure ...

#29. A Comparison of Patient Characteristics Between Glp-1 Ra ...

In China, while insulin has been prescribed for decades, glucagon-like peptide 1 receptor agonists (GLP-1-RA) have been available as an injectable treatment ...

#30. Another Positive GLP-1 RA CVOT: The AMPLITUDE-O Trial

Numerous cardiovascular outcome trials (CVOTs) have shown not only the safety of GLP-1 receptor agonists (GLP-1 RAs) in the management of people ...

#31. Diabetes Distilled: AMPLITUDE-O: Increasing the wavelength ...

The AMPLITUDE-O trial explored the effect of efpeglenatide, an exendin-based, once-weekly GLP-1 RA currently in development, on cardiovascular and renal ...

#32. Longer Acting GLP-1 Agonists and Improved CV Outcomes

Antibody Development in Subjects Treated With LA-GLP1 RA. As with all therapeutic peptides, there has been ongoing concern as to whether the development of ...

#33. Inequities Seen in GLP-1 RA Use for Type 2 Diabetes in the US

Asian, Black, Hispanic, and low-income patients less likely to receive treatment with a glucagon-like peptide-1 receptor agonist for T2DM.

#34. Are all GLP-1 agonists equal in the treatment of type 2 diabetes?

GLP -1 RA. C. E. F. A. B. D. G. H. I. Figure 3. Clinical efficacy results from clinical trials comparing different GLP-1 receptor agonists head-to-head.

#35. Analysis Highlights Disparities in GLP-1 RA Access

An analysis uncovered racial, ethnic, and socioeconomic inequities regarding access to glucagon-like peptide-1 receptor agonists among US ...

#36. What Are GLP-1 Agonists and How Do They Work? - Verywell ...

Learn how GLP-1 agonists, a type of non-insulin injectable medication, can help lower blood sugar and aid weight loss for people with type 2 ...

#37. The effects of DPP-4 inhibitors, GLP-1 receptor agonists and ...

GLP -1RA and SGLT2i (two new diabetes medicines) are likely to reduce the risk of death from cardiovascular disease and death from any cause ...

#38. GLP-1 RA treatment: a benefit-risk analysis from a ... - EASD

GLP -1 RA treatment: a benefit-risk analysis from a retrospective cohort study. Abstract # 749. Session: GLP1 receptor agonists: How good are they in real ...

#39. 당뇨병 주사제: Glucagon-Like Peptide-1 수용체작용제

of Diabetes guideline for treatment of diabetes, glucagon-like peptide-1 receptor agonist (GLP-. 1 RA) is recommended in diabetic patients with established ...

#40. GLP-1 analogues | Diabetes UK

GLP -1's (incretin mimetics) This type of medication works by increasing the levels of hormones called 'incretins'. These hormones help the body produce more ...

#41. The Effect of Early Response to GLP-1 RA Therapy on ... - JMCP

Early glycemic controls and treatment intensification with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) result in long-term clinical and economic ...

#42. What GPs need to know about GLP-1 RAs - RACGP

' Administered via injection, GLP-1 RAs work by mimicking the effects of the hormone GLP-1 produced in the body when eating, stimulating the ...

#43. Safety and Efficacy of Glucagon-Like Peptide-1 Receptor ...

We originally aimed to include all clinical trials that explored the use of GLP-1RA (eg, exenatide, lixisenatide, dulaglutide, ...

#44. Preference for Oral and Injectable GLP-1 RA Therapy Profiles ...

Many injectable therapies of the glucagon-like peptide 1 (GLP-1) receptor agonist (RA) class (including semaglutide, dulaglutide, exenatide, ...

#45. GLP-1 receptor agonists (GLP1RA) - Type 2 Diabetes ...

Therefore, GLP1 receptor agonists (GLP1RA) should be strongly considered in all patients with diabetic renal disease (urinary albumin:creatinine ratio > 3 ...

#46. GLP-1 Receptor Agonists in Diabetic Kidney Disease - KDIGO

ARB, angiotensin II receptor blocker; ACE, angiotensin-converting enzyme; GLP1-RA, glucagon-like peptide 1 receptor agonist;.

#47. Mechanisms of Action and Therapeutic Application of ...

GLP -1 was found to exhibit incretin-like activity, potentiating glucose-dependent insulin secretion in normal and diabetic animals and ...

#48. Understanding the place for GLP‐1RA therapy: Translating ...

Abstract Since the first glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) was approved in 2005 (exenatide twice daily) for type 2 ...

#49. FDA approves first oral GLP-1 treatment for type 2 diabetes

Rybelsus is the first glucagon-like peptide (GLP-1) receptor protein treatment approved for use in the United States that does not need to ...

#50. The Use of SGLT2i and GLP-1 RA in Patients with Type 2 ...

Both sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) improve key outcomes including major CV ...

#51. GLP-1-receptor agonister (GLP-1-RA) og DPP-IV-hæmmere

Glucagon Like Peptide 1 (GLP-1) fremmer den glucosestimulerede insulinsekretion samtidig med, at glucagonfrisætningen hæmmes.

#52. GLP-1-Patient-Leaflet - Manor Primary Care

GLP -1 RA? You and your healthcare team have agreed that you should take a medication for your type 2 diabetes that belongs to a group of medicines.

#53. GLP-1 Receptor Agonists | diaTribe

GLP -1 receptor agonists are a type of medication that people with type 2 diabetes can use to lower blood sugar levels. How do GLP-1 receptor ...

#54. Investigational GLP-1 RA Cuts Heart, Renal Risk in ...

An investigational glucagon-like peptide-1 (GLP-1) receptor agonist had significant heart and kidney benefits in an already compromised ...

#55. Low Use of GLP-1 RAs Observed in Treatment of Type 2 ...

Accordingly, a recent study evaluated the uptake of glucagon-like peptide-1 receptor agonists (GLP-1 RA) in a commercially insured ...

#56. GLP-1 Receptor Agonist

Liraglutide usually started at 0.6 mg once daily for 1 week then increase to 1.2 mg once daily. • Exenatide usually started at 5 ug taken twice daily within ...

#57. GLP-1 receptor agonists for type 2 diabetes currently available ...

Xultophy are two combination pen devices that deliver a GLP-1 RA and basal insulin simultaneously allowing a robust reduction of HbA1c when.

#58. Why Choose a GLP-1 RA | For HCPs

Glucagon-like peptide -1 (GLP-1) is a key incretin hormone that stimulates glucose-dependent insulin secretion; however, in patients with T2D or impaired glucose ...

#59. Managing the gastrointestinal side effects of GLP-1 receptor ...

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are well established in ... such as treatment with a GLP-1RA, for achievement of weight loss and for ...

#60. GLP-1 RA use in acute myocardial infarction - Medicine ...

Glucagon-like peptide -1 receptor agonists (GLP-1 RAs) are a commonly used class of glucose-lowering medications which have proven cardiovascular ...

#61. Comparison of INVOKANA to GLP-1 Receptor Agonists

Two retrospective, real-world analyses compared A1c control and medication costs between T2DM patients treated with INVOKANA 300 mg vs a GLP-1 RA. Similar ...

#62. GLP-1 RA: Similitudini e differenze tra le diverse molecole

GLP -1RA, glucagon-like peptide-1 receptor agonist. Renukuntla et al. Int J Pharm. 2013, Buckley ST et al. Sci Transl Med 2018;10:eaar7047.doi:10.1126/ ...

#63. First oral GLP-1 treatment for type 2 diabetes

It is the first glucagon-like peptide (GLP-1) receptor agonist treatment - a class of non-insulin medicines for people with type 2 diabetes ...

#64. EFFECT OF A GLP-1 RECEPTOR AGONIST AND SGLT-2 ...

Administration of the maximum dose of a GLP-1RA on top of SGLT-2i treatment compared to SGLT-2i alone resulted in a significant decrease in systolic blood ...

#65. 【篤實關懷倫理卓越】光田綜合醫院Kuang Tien General Hospital

Soliqua內含作用機轉互補的兩種活性成分以改善血糖控制：insulin glargine，它是一種基礎胰島素類似物(主要針對空腹血糖)及lixisenatide，此為類升糖素胜肽-1(GLP-1)受體促 ...

#66. Receptor Agonists as Adjunct in Type 1 Diabetes

Participants used either basal bolus insulin or continuous subcutaneous insulin infusion (CSII). Liraglutide is a GLP-1 RA and is sold under the ...

#67. GLP-1 RA Tablet

The GLP-1 RAs mimic how the body naturally responds to blood glucose, working when the body needs it 1. GLP-1 RAs reduce blood glucose by stimulating insulin ...

#68. Insulin, GLP-1 RA Combo Improves Blood Sugar Control for ...

Real-world evidence shows that the combination of insulin and GLP-1RA therapies helped patients improve blood sugar levels compared to ...

#69. GLP-1 RA options: Similarities and Differences

GIP = glucose-dependent insulinotropic peptide; GLP-1 = glucagon-like peptide-1. 1. Drucker DJ. Diabetes Care. 2003;26:2929–2940. 2. Meier JJ et al. Best Pract ...

#70. GLP-1 Agonists Decreased MACE and CV Death in Type 2 ...

Patients with type 2 diabetes (T2D) who were treated with glucagon-like peptide-1 receptor agonists (GLP-1 RA) had significantly fewer ...

#71. SciELO - Brasil - Making a case for the combined use of ...

Sodium glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor agonists (GLP-1RA) were initially approved to improve glycemic control in ...

#72. Analysis of GLP-1 RA and SGLT2i in T2DM | Endocrine Society

Cardiovascular outcome trials (CVOT) of glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose cotransporter 2 inhibitors ...

#73. SUSTAIN-10 Post-hoc Analysis Suggests Additive Benefits for ...

... weight, and BP in T2D patients prescribed GLP-1 receptor agonists who ... Suggests Additive Benefits for GLP-1 RA-SGLT-2i Combination.

#74. GLP-1 Receptor Agonists: An Alternative for Rapid-Acting ...

GLP -1 RAs have effects on both fasting and prandial blood glucose levels. ... They are also associated with a significant potential to lower A1C.

#75. Soliqua® Phase 3 results significantly lowered blood sugar ...

PARIS - June 9, 2019 - In a Phase 3 study evaluating adults with type 2 diabetes inadequately controlled by GLP-1 receptor agonist (GLP-1 RA) ...

#76. Reasons for discontinuation of GLP1 receptor agonists - Dove ...

Abbreviations: GLP1 RA, glucagon-like peptide-1 receptor agonist; T2DM, type 2 diabetes mellitus. Table 1 Patient demographics and clinical ...

#77. The Clinical Impact of GLP-1 Receptor Agonists in Type 2 ...

Liraglutide and semaglutide have beneficial effects in cardiovascular outcome trials. Exenatide. Exenatide was the first GLP-1 RA approved for ...

#78. Mechanism of Action for GLP 1 RAs: "The How" - YouTube

#79. Anti-Inflammatory Effects of GLP-1-Based Therapies beyond ...

Glucagon-like peptide -1 (GLP-1) is an incretin hormone mainly secreted from intestinal L cells in response to nutrient ingestion. GLP-1 has beneficial ...

#80. 口服GLP-1 RAs (oral semaglutide) - 血糖藥的明日之星? - ADA ...

Semaglutide 皮下注射為每週一次(sc. QW)，還有另一種劑型：口服semaglutide ，是第一個口服GLP-1 RA。小分子胜肽或蛋白質藥物經口服給藥，必需經過胃腸道 ...

#81. cardiologist use of sglt2 inhibitors and glp-1 receptor agonists ...

Cardiologists predominantly used SGLT2i over GLP-1RA (2.6:1), unlike non-cardiology prescribers (0.9:1); empagliflozin alone accounted for 72% ...

#82. GLP-1 Resources - Association of Diabetes Care & Education ...

GLP -1 Receptor Agonists. GLP1 Resources. Hyperglycemia, or high blood sugar, can be a deadly complication for anyone living with diabetes, but there are ...

#83. GLP-1 RECEPTOR AGONIST THERAPY IN TYPE 2 DIABETES

The choice of GLP-1Ra OW or OD will be based on clinical considerations and patient preferences. (To be used in conjunction with existing guidelines and ...

#84. In type 2 diabetes, GLP-1 RA plus SGLT2 inhibitor vs. either ...

In adults with type 2 diabetes, is the combination of a glucagon-like peptide-1 receptor agonist (GLP-1 RA) and a sodium–glucose ...

#85. GLP-1 RA - 臨床筆記

在已確診ASCVD或已確診腎臟疾病的T2DM患者中，推薦SGLT2-i或GLP-1 RA作為綜合心血管風險降低和/或降糖方式，對心血管疾病有益。(A).

#86. glp-1_analogs [TUSOM | Pharmwiki] - TMedWeb

It has been observed that short acting GLP-1 receptor agonists exert their primary hypoglycemic effect by lowering postprandial glucose due to ...

#87. GLP-1 Receptor Agonist: Apakah Hanya Bermanfaat Untuk ...

Glucagon like peptide-1 Receptor Agonist (GLP-1RA) merupakan salah satu agen incretin based therapy. GLP-1RA sudah direkomendasikan oleh ...

#88. 比較GLP1-RA與SGLT2i在預防第二型糖尿病患者的重大心血管 ...

Abstract. Background: Glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose contransporter-2 inhibitors (SGLT2i) have ...

#89. Four Facts to Remember Before Prescribing a GLP-1 Agonist

Therefore, some GLP-1 agonists are strictly contraindicated in patients with MEN syndrome type 2 or personal or family history of thyroid cancer ...

#90. GLP-1 Agonists | DrugBank Online

Glucagon-like peptide -1 receptor agonists also known as GLP-1 receptor agonists or incretin mimetics are agonists of the GLP-1 receptor.

#91. 全球首个基础胰岛素GLP-1RA注射液正式在中国供货！

近日，全球首个基础胰岛素胰高糖素样肽-1受体激动剂（GLP-1RA）注射液诺和益® (德谷胰岛素利拉鲁肽注射液)正式在中国供货。诺和诺德中国将加速推动诺 ...

#92. Tips for Taking GLP-1 RAs for Type 2 Diabetes - WebMD ...

Want some tips on managing your type 2 diabetes? Learn easy tips on how to take a GLP-1 RA and how it can help manage diabetes.

#93. Semaglutide…GLP-1 receptor agonist ชนิดแรกที่เป็นยา ...

Glucagon-like peptide -1 (GLP-1) เป็นฮอร์โมนในกลุ่ม incretins (หมายถึงกลุ่มฮอร์โมนในทางเดินอาหารที่มีฤทธิ์ลดน้ำตาลในเลือด) หลั่งโดย L cell ...

#94. Oral GLP-1 RA lowers Weight and A1c - Diabetes Education ...

Semaglutide (Ozempic) is currently only available as a once a week injectable, belonging to the GLP-1 Receptor Agonists classification.

#95. Small-molecule agonists for the glucagon-like peptide 1 receptor

Glucagon-like peptide (GLP)-1 is a 30-aa peptide hormone synthesized in l-cells of the small intestine (1). GLP-1, one of the incretins, is a natural ...

#96. A Subanalysis of LixiLan-L.,Diabetes Therapy - X-MOL

Glucagon-like peptide -1 receptor agonists such as lixisenatide that do ... Fixed-Ratio Combination of Insulin and GLP-1 RA in Patients with ...