chimerichemagglutininprotein的八卦，YOUTUBE和Yahoo名人娛樂都在討論

#11. Immunogenicity of chimeric haemagglutinin ... - The Lancet

Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. Proc Natl Acad Sci USA. 2013; 110: ...

#12. Review of a Chimeric Hemagglutinin-Based Influenza Vaccine ...

Two important proteins on the surface of the virus include hemagglutinin (HA) and. Neuraminidase (NA), which are key to host cell entry and infection (Figure 1) ...

#13. A chimeric hemagglutinin-based universal influenza virus ...

Request PDF | A chimeric hemagglutinin-based universal influenza virus vaccine ... immunodominant globular head domain of the viral hemagglutinin protein.

#14. Broad cross-protection by recombinant influenza viruses ...

expressing conserved M2e- hemagglutinin chimera and virus-like ... proteins from human adapted influenza viruses bind preferentially to α-2 ...

#15. Chimeric influenza virus-like particles comprising hemagglutinin

The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid ...

#16. Chimeric Hemagglutinin-Based Influenza Virus Vaccines ...

T cells can recognize epitopes derived from highly conserved internal virus proteins in the context of MHC and, therefore, can be activated against a wide ...

#17. The potential of a universal influenza virus-like particle ...

The hemagglutinin (HA) protein, which serves as the major antigen of ... created a chimeric cytokine (CC) consisting of IL-12, M2 protein, ...

#18. Influenza Chimeric Protein (3M2e-3HA2-NP) Adjuvanted with ...

Vaccination is the most effective way to prevent influenza virus infections. However, conventional vaccines based on hemagglutinin (HA) have to be annually ...

#19. Mount Sinai Researchers Advance a Universal Influenza Virus ...

The chimeric HA vaccine seeks to correct this uncertainty by targeting a different part of the hemagglutinin protein, the major surface ...

#20. Adjuvants and Immunization Strategies to Induce Influenza ...

Different combinations of chimeric hemagglutinin proteins, all sharing a common ... Sequential chimeric HA protein immunizations induce a ...

#21. Chimeric influenza virus hemagglutinin containing either the ...

Viral glycoproteins such as vesicular stomatitis virus (VSV). G protein and influenza hemagglutinin (HA) have been ex- tensively used to elucidate the ...

#22. Production and purification of chimeric HBc virus-like particles ...

Purified VLPs induced strong antibody responses against both group 1 and group 2 HA proteins in mice. Conclusion: Our results indicate that the tandem core ...

#23. Construction of the vaccine strain of the influenza B virus with ...

One of the promising approaches is sequential vaccination with chimeric influenza viruses with identical stem domains of the hemagglutinin surface protein.

#24. Designing of Chimeric Vaccine against Canine Distemper ...

Viral hemagglutinin protein sequences were retrieved from the Uniprot database, and conserved regions were identified. Possible B-cell epitope.

#25. Universal influenza virus vaccine: Strong and durable results ...

The chimeric HA vaccine seeks to correct this uncertainty by targeting a different part of the hemagglutinin protein, the major surface ...

#26. A single-shot adenoviral vaccine provides hemagglutinin stalk ...

mismatched, reassortant influenza virus bearing a chimeric. HA, cH6/1, in a stalk-mediated ... HA is a homotrimeric protein composed of two domains, the re-.

#27. First-in-human Study Has Good News for Universal Flu Vaccine

The immunodominant head domain of the viral hemagglutinin protein, ... especially with adjuvanted inactivated chimeric hemagglutinin ...

#28. A chimeric hemagglutinin-based universal influenza virus ...

A chimeric hemagglutinin-based universal influenza virus vaccine approach ... globular head domain of the viral hemagglutinin protein.

#29. Basolateral expression of a chimeric protein in which the ...

Two integral membrane proteins, influenza virus hemagglutinin (HA) and vesicular stomatitis virus G protein, are transported to and ...

#30. Universal Influenza Vaccines | Encyclopedia MDPI

For vaccines that mainly activate humoral immune responses, such as those based on chimeric HA and M2e proteins, an adjuvant that activates antibody ...

#31. Flu Vaccines: What Does the Future Hold?

One such study in humans showed that vaccination with a live attenuated virus containing a chimeric HA protein with a heterologous head but ...

#32. Chimeric influenza-virus-like particles containing the porcine ...

The HA and M1 proteins from the H3N2 influenza virus and the PRRSV GP5 protein fused to the cytoplasmic and transmembrane domains of the NA ...

#33. Hemagglutinin head-specific responses dominate over stem ...

Studies have shown that prime-boost vaccination with divergent influenza viruses or chimeric influenza HA proteins can boost HA stem Ab ...

#34. A stable trimeric influenza hemagglutinin stem as a broadly ...

... to flu: the “head” region of the viral hemagglutinin (HA) protein. ... chimeric HAs (15, 16), epitope transplantation on a virus-like particle (17), ...

#35. Polarized expression of a chimeric protein in which ... - Typeset

In virus-infected cells, the envelope proteins, influenza hemagglutinin (HA) ... transmembrane and cytoplasmic domains of VSV G. When the chimeric protein ...

#36. Generation of Stable Influenza Virus Hemagglutinin through ...

Thus, these novel recombinant chimeric proteins generated by noncontiguous SCHEMA recombination can serve as better vaccine antigens to tackle ...

#37. TOWARDS A UNIVERSAL INFLUENZA VIRUS VACCINE - isirv

antibodies using chimeric HA constructs in mice. PR8 H1N1(1934) ... cH9/1 DNA + H1 protein/cH6/1 protein + cH5/1 protein/H1 protein. cH9/1 DNA + BSA +BSA.

#38. New universal flu vaccine targets conserved region of viral ...

Our chimeric HA vaccine, by contrast, is directed at the proximal part of the HA protein -- the stalk domain -- which has been shown to ...

#39. A chimeric hemagglutinin-based universal influenza virus ...

... globular head domain of the viral hemagglutinin protein. ... A chimeric hemagglutinin-based universal influenza virus vaccine approach ...

#40. A A212T Substitution in Hemagglutinin Impacts on the Rescue ...

In substitution for alanine at residue 212 in the chimeric HA protein of rA/B-California/04/2009 virus, threonine was identi ed as a deleterious ...

#41. Antigenic landscape analysis of individuals vaccinated with a ...

A chimeric hemagglutinin (cHA) – based candidate universal influenza ... these samples using an influenza virus protein microarray (IVPM), ...

#42. Endocytosis of chimeric influenza virus hemagglutinin proteins ...

The influenza virus A/Japan/305/57 hemagglutinin (HA) can be converted from a protein that is essentially excluded from coated pits into one ...

#43. Progress towards the Development of a Universal Influenza ...

consists of hemagglutinin (HA) and neuraminidase (NA) proteins. ... and MVA vector vaccines containing a combination of chimeric HA, NP, ...

#44. Universal Influenza Virus Vaccines That Target the Conserved ...

A vaccination strategy based on chimeric hemagglutinin (cHA), ... as well as internal proteins that harbor strong and dominant T-cell ...

#45. Influenza Viruses: Targetting Conserved Viral Ha-Stem, Matrix ...

These segments encode viral proteins including hemagglutinin (HA), ... and chimeric HA proteins approach to stem-based universal vaccine design.

#46. Influenza virus hemagglutinin stalk-based antibodies and ...

in a headless HA protein that partially protected mice from viral challenge. ... Chimeric HA based vaccination strategy in animal models.

#47. Immunogenicity of chimeric haemagglutinin ... - eScholarship

Several clinical trials with broadly protective influenza virus vaccine candidates based on internal viral proteins or peptides that trigger T- ...

#48. Toward a Universal Influenza Virus Vaccine - Annual Reviews

The M2 protein of influenza A virus is a transmembrane, homotetrameric proton ion channel ... Induction of Stalk Antibodies Using Chimeric Hemagglutinins.

#49. Immunogenicity of modified vaccinia virus Ankara expressing ...

Vaccination regimens based on these chimeric HA structures have been ... recombinant HA protein from CA/09 virus or CA/09 virus-loaded and ...

#50. Protective Immunity Based on the Conserved Hemagglutinin ...

(2012) prove this by developing chimeric hemagglutinin of H3 globular head ... LAH is the highly conserved region of HA2 of hemagglutinin protein of H3 and ...

#51. Receptor-Specific Targeting Mediated by the Coexpression of ...

Here, we report the use of a binding-defective but fusion-competent hemagglutinin (HA) protein to complement the fusion defect in a chimeric ...

#52. Vaccine - Oxford University Research Archive

chimeric hemagglutinin and nucleoprotein plus matrix protein 1 in a mouse model against challenge with group 2 influenza viruses including ...

#53. EMDB < EMD-6612 - EMBL-EBI

Chimeric hemagglutinin proteins are set to undergo human clinical trials as a universal influenza vaccine candidate, yet no structural information for these ...

#54. CHIMERIC INFLUENZA VIRUS-LIKE PARTICLES ...

like particles comprising chimeric influenza hemagglutinin, ... linked to a sequence encoding a chimeric HA protein include those.

#55. Researchers Advance a Universal Influenza Virus Vaccine

The chimeric HA vaccine seeks to correct this uncertainty by targeting a different part of the hemagglutinin protein, the major surface ...

#56. Is It Possible to Develop a “Universal” Influenza Virus Vaccine?

Discovery of conserved antigenic sites on the hemagglutinin (HA) protein for ... Another interesting new approach is using chimeric HA molecules in which ...

#57. Emerging influenza viruses and the prospect of a universal ...

Chimeric HA -based vaccines can be produced using a variety of platforms ... platforms for a headless HA vaccine are recombinant protein, ...

#58. Development of a Universal Influenza Vaccine

One advantage of utilizing chimeric HA proteins is that people who have had natural influenza infection will already have some baseline ...

#59. Hemagglutinin (influenza) - Wikipedia

The first three hemagglutinins, H1, H2, and H3, are found in human influenza viruses. By phylogenic similarity, the HA proteins are divided into 2 groups, with ...

#60. Custom Recombinant Protein Expression Services

Sino Biological custom recombinant protein expression services offer ... Title: The interaction of influenza H5N1 viral hemagglutinin with sialic acid ...

#61. Influenza Hemagglutinin - Stephen Harrison (Harvard/HHMI)

https://www.ibiology.org/microbiology/virus-structures/#part-2Hemagglutinin has three functions: receptor binding, antigenic variation, ...

#62. The Influenza Virus and Hemagglutinin Protein - YouTube

https://www.ibiology.org/microbiology/virus-structures/#part-1Stephen Harrison of Harvard Medical School describes the influenza virus and ...

#63. The Positive Sense Single Stranded RNA Viruses

However, no chimeric omegatetraviruses have yet been detected. ... S, spike protein; M, large membrane protein; HE, hemagglutinin-esterase; N, ...

#64. Hemagglutinin Proteins - antibodies-online

HA 宿主: Influenza Virus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. 显示详细信息.

#65. Henipavirus—Advances in Research and Treatment: 2012 ...

However, the hemagglutinin-neuraminidase (HN) attachment protein of NDV ... “Chimeric proteins composed of domains from the two attachment proteins have ...

#66. Bats and Viruses: A New Frontier of Emerging Infectious Diseases

Notably, the HA and NA‐like (NAL) molecules of the newly detected bat ... two chimeric genes encoding the hemagglutinin and neuraminidase proteins from ...

#67. Measles: New Insights for the Healthcare Professional: 2012 ...

(2011 MAY 9) University of Paris: A chimeric measles virus with a ... The presence of SIV gp160 as the only envelope protein on chimeric particles surface ...

#68. Structure-Function Relationships of Human Pathogenic Viruses

Peebles, 1991, Paramyxovirus M proteins. ... R., 2000, Characterization of a region of the measles virus hemagglutinin sufficient for its dimerization.

#69. Cumulated Index Medicus - 第 27 卷 - 第 10759 頁 - Google 圖書結果

( Isolation and study of the properties of the hemagglutinins Dec 27 ; 85 ( 2 ) ... Possee RD . localization of carbohydrate - binding protein 35 in 3T3 of ...

#70. Viral Infections of Humans: Epidemiology and Control

A chimeric alphavirus replicon particle vaccine expressing the hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques from measles.

#71. Animal Biotechnology: Comprehensive Biotechnology, First ...

A chimeric gene containing vaccinia virus transcriptional regulatory sequences and foreign protein coding sequences is constructed in vitro and inserted ...

#72. Mandell, Douglas, and Bennett's Principles and Practice of ...

... another chimeric virus based on the HPIV-3-cp45 virus has been studied and ... Antigenic variation in the hemagglutinin-neuraminidase protein of human ...

#73. Sequences of Proteins of Immunological Interest

42) B6.2: THE V-REGIONS WERE USED TO CONSTRUCT A MURINE/HUMAN CHIMERIC ... THE VIRUS NEUTRALIZING EPITOPE ON THE MAMMALIAN REOVIRUS TYPE 3 HEMAGGLUTININ.