瑜珈改變基因表達
Yoga Changes the Gene Expression (English Below)
許多研究發現瑜珈對於身體及心理的幫助是有益的,但實際生化機制上是一個謎。挪威的奧斯陸大學最新研究顯示瑜珈練習對於基因表達(特別是免疫細胞)有快速及衝擊性的影響;這些數據顯示瑜珈練習的療癒效應會立即且全面性的影響身體的分子結構。
首先,瑜珈練習並不會改變你的基因,也就是下犬式做久了你不會變成一條狗,但瑜珈練習會影響你的基因表達(genetic expression)。何謂基因表達? DNA像是一部電影的膠卷,RNA像是電影的投射機,那麼製造出來的蛋白質變像是一部聲色俱佳的電影,這部電影就是基因的表達。換句話說,基因會像燈一樣被打開和關閉。
瑜珈的練習會造成一些基因的啟動,特別是免疫系統。
奧斯陸大學的研究了十名測試者,前兩天他們參與了兩小時的瑜珈練習,練習前後的抽血報告顯示,有111種的基因表達因此而改變 (Peripheral blood mononuclear cell 外週血單核細胞)。幾天後,他們讓這些測試者連續兩天在森林散步二小時,聽音樂放鬆,測試前後的抽血報告發現只有38樣基因表達被改變*。此項研究顯示瑜 珈是有效及快速地在基因層面提供對健康有益的因子。研究者說: 比起一般傳統的放鬆方式,瑜珈的練習在分子結構上影響較為廣泛。
Researchers first reported five years ago that practices such as yoga which elicit the “relaxation response” may have a long-term effect on gene expression. That’s the scientific term for whether a specific gene is “turned on,” meaning its protein or RNA product is being made. This latest study confirms those findings, links them to the body’s immune system, and suggests this effect may be instantaneous.
First of all, yoga doesn’t change your Gene (you won’t turn into a dog doing downward facing dog) but it will affect your gene expression. What is Gene expression ? DNA is like a film of a movie, RNA is like the movie projector and the protein it created is like a movie. The movie is the expression of the gene. In other words, the gene can be turned on and off like a light switch.
The University of Oslo experiment featured 10 participants who attended a week-long yoga retreat in Germany. For the first two days, participants spent two hours practicing a comprehensive yoga program including yogic postures (asanas), yogic breathing exercises (in particular Sudarshan Kriya), and meditation. For the next two days, they spent that same time period going on an hour-long nature walk and then listening to either jazz or classical music.
Immediately before and after each of the four sessions, the researchers drew blood from each participant. They then isolated and analyzed peripheral blood mononuclear cells, which play a key role in the body’s immune system. The researchers found that the nature walk and music-driven relaxation changed the expression of 38 genes in these circulating immune cells. In comparison, the yoga produced changes in 111. *
The two regimens, to some degree, affect similar biological processes,” the researchers write. That said, they note that yoga's impact was far more widespread, which indicates the practice “may have additional effects over exercise plus simple relaxation in inducing health benefits through differential changes at the molecular level.”
* http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061910
同時也有10000部Youtube影片,追蹤數超過62萬的網紅Bryan Wee,也在其Youtube影片中提到,...
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146 Reasons Why Sugar Is Ruining Your Health
146 เหตุผลที่เราไม่ควรกินน้ำตาล
By Nancy Appleton, Ph.D.
(สำหรับคนที่ยังคิดว่ามันมีข้อดีบ้างครับ อาหารทุกชนิดมีข้อดีบ้าง เพียงแต่ว่าเราต้องชั่งข้อดีกับข้อเสียกันครับ)
1. Sugar can suppress the immune system.
2. Sugar upsets the mineral relationships in the body.
3. Sugar can cause hyperactivity, anxiety, difficulty concentrating, and crankiness in children.
4. Sugar can produce a significant rise in triglycerides.
5. Sugar contributes to the reduction in defense against bacterial infection (infectious diseases).
6. Sugar causes a loss of tissue elasticity and function, the more sugar you eat the more elasticity and function you loose.
7. Sugar reduces high density lipoproteins.
8. Sugar leads to chromium deficiency.
9 Sugar leads to cancer of the ovaries.
10. Sugar can increase fasting levels of glucose.
11. Sugar causes copper deficiency.
12. Sugar interferes with absorption of calcium and magnesium.
13. Sugar can weaken eyesight.
14. Sugar raises the level of a neurotransmitters: dopamine, serotonin, and norepinephrine.
15. Sugar can cause hypoglycemia.
16. Sugar can produce an acidic digestive tract.
17. Sugar can cause a rapid rise of adrenaline levels in children.
18. Sugar malabsorption is frequent in patients with functional bowel disease.
19. Sugar can cause premature aging.
20. Sugar can lead to alcoholism.
21. Sugar can cause tooth decay.
22. Sugar contributes to obesity
23. High intake of sugar increases the risk of Crohn's disease, and ulcerative colitis.
24. Sugar can cause changes frequently found in person with gastric or duodenal ulcers.
25. Sugar can cause arthritis.
26. Sugar can cause asthma.
27. Sugar greatly assists the uncontrolled growth of Candida Albicans (yeast infections).
28. Sugar can cause gallstones.
29. Sugar can cause heart disease.
30. Sugar can cause appendicitis.
31. Sugar can cause multiple sclerosis.
32. Sugar can cause hemorrhoids.
33. Sugar can cause varicose veins.
34. Sugar can elevate glucose and insulin responses in oral contraceptive users.
35. Sugar can lead to periodontal disease.
36. Sugar can contribute to osteoporosis.
37. Sugar contributes to saliva acidity.
38. Sugar can cause a decrease in insulin sensitivity.
39. Sugar can lower the amount of Vitamin E (alpha-Tocopherol in the blood.
40. Sugar can decrease growth hormone.
41. Sugar can increase cholesterol.
42. Sugar can increase the systolic blood pressure.
43. Sugar can cause drowsiness and decreased activity in children.
44. High sugar intake increases advanced glycation end products (AGEs)(Sugar bound non-enzymatically to protein)
45. Sugar can interfere with the absorption of protein.
46. Sugar causes food allergies.
47. Sugar can contribute to diabetes.
48. Sugar can cause toxemia during pregnancy.
49. Sugar can contribute to eczema in children.
50. Sugar can cause cardiovascular disease.
51. Sugar can impair the structure of DNA
52. Sugar can change the structure of protein.
53. Sugar can make our skin age by changing the structure of collagen.
54. Sugar can cause cataracts.
55. Sugar can cause emphysema.
56. Sugar can cause atherosclerosis.
57. Sugar can promote an elevation of low density lipoproteins (LDL).
58. High sugar intake can impair the physiological homeostasis of many systems in the body.
59. Sugar lowers the enzymes ability to function.
60. Sugar intake is higher in people with Parkinson’s disease.
61. Sugar can cause a permanent altering the way the proteins act in the body.
62. Sugar can increase the size of the liver by making the liver cells divide.
63. Sugar can increase the amount of liver fat.
64. Sugar can increase kidney size and produce pathological changes in the kidney.
65. Sugar can damage the pancreas.
66. Sugar can increase the body's fluid retention.
67. Sugar is enemy #1 of the bowel movement.
68. Sugar can cause myopia (nearsightedness).
69. Sugar can compromise the lining of the capillaries.
70. Sugar can make the tendons more brittle.
71. Sugar can cause headaches, including migraine.
72. Sugar plays a role in pancreatic cancer in women.
73. Sugar can adversely affect school children's grades and cause learning disorders..
74. Sugar can cause an increase in delta, alpha, and theta brain waves.
75. Sugar can cause depression.
76. Sugar increases the risk of gastric cancer.
77. Sugar and cause dyspepsia (indigestion).
78. Sugar can increase your risk of getting gout.
79. Sugar can increase the levels of glucose in an oral glucose tolerance test over the ingestion of complex carbohydrates.
80. Sugar can increase the insulin responses in humans consuming high-sugar diets compared to low sugar diets.
81 High refined sugar diet reduces learning capacity.
82. Sugar can cause less effective functioning of two blood proteins, albumin, and lipoproteins, which may reduce the body’s ability to handle fat and cholesterol.
83. Sugar can contribute to Alzheimer’s disease.
84. Sugar can cause platelet adhesiveness.
85. Sugar can cause hormonal imbalance; some hormones become underactive and others become overactive.
86. Sugar can lead to the formation of kidney stones.
87. Sugar can lead to the hypothalamus to become highly sensitive to a large variety of stimuli.
88. Sugar can lead to dizziness.
89. Diets high in sugar can cause free radicals and oxidative stress.
90. High sucrose diets of subjects with peripheral vascular disease significantly increases platelet adhesion.
91. High sugar diet can lead to biliary tract cancer.
92. Sugar feeds cancer.
93. High sugar consumption of pregnant adolescents is associated with a twofold increased risk for delivering a small-for-gestational-age (SGA) infant.
94. High sugar consumption can lead to substantial decrease in gestation duration among adolescents.
95. Sugar slows food's travel time through the gastrointestinal tract.
96. Sugar increases the concentration of bile acids in stools and bacterial enzymes in the colon. This can modify bile to produce cancer-causing compounds and colon cancer.
97. Sugar increases estradiol (the most potent form of naturally occurring estrogen) in men.
98. Sugar combines and destroys phosphatase, an enzyme, which makes the process of digestion more difficult.
99. Sugar can be a risk factor of gallbladder cancer.
100. Sugar is an addictive substance.
101. Sugar can be intoxicating, similar to alcohol.
102. Sugar can exacerbate PMS.
103. Sugar given to premature babies can affect the amount of carbon dioxide they produce.
104. Decrease in sugar intake can increase emotional stability.
105. The body changes sugar into 2 to 5 times more fat in the bloodstream than it does starch.
106. The rapid absorption of sugar promotes excessive food intake in obese subjects.
107. Sugar can worsen the symptoms of children with attention deficit hyperactivity disorder (ADHD).
108. Sugar adversely affects urinary electrolyte composition.
109. Sugar can slow down the ability of the adrenal glands to function.
110. Sugar has the potential of inducing abnormal metabolic processes in a normal healthy individual and to promote chronic degenerative diseases.
111.. I.Vs (intravenous feedings) of sugar water can cut off oxygen to the brain.
112. High sucrose intake could be an important risk factor in lung cancer.
113. Sugar increases the risk of polio.
114. High sugar intake can cause epileptic seizures.
115. Sugar causes high blood pressure in obese people.
116. In Intensive Care Units, limiting sugar saves lives.
117. Sugar may induce cell death.
118. Sugar can increase the amount of food that you eat.
119. In juvenile rehabilitation camps, when children were put on a low sugar diet, there was a 44% drop in antisocial behavior.
120. Sugar can lead to prostrate cancer.
121. Sugar dehydrates newborns.
122. Sugar increases the estradiol in young men.
123. Sugar can cause low birth weight babies.
124. Greater consumption of refined sugar is associated with a worse outcome of schizophrenia
125. Sugar can raise homocysteine levels in the blood stream.
126. Sweet food items increase the risk of breast cancer.
127. Sugar is a risk factor in cancer of the small intestine.
128. Sugar may cause laryngeal cancer.
129. Sugar induces salt and water retention.
130. Sugar may contribute to mild memory loss.
131. As sugar increases in the diet of 10 years olds, there is a linear decrease in the intake of many essential nutrients.
132. Sugar can increase the total amount of food consumed.
133. Exposing a newborn to sugar results in a heightened preference for sucrose relative to water at 6 months and 2 years of age.
134. Sugar causes constipation.
135. Sugar causes varicous veins.
136. Sugar can cause brain decay in prediabetic and diabetic women.
137. Sugar can increase the risk of stomach cancer.
138. Sugar can cause metabolic syndrome.
139. Sugar ingestion by pregnant women increases neural tube defects in embryos.
140. Sugar can be a factor in asthma.
141. The higher the sugar consumption the more chances of getting irritable bowel syndrome.
142. Sugar could affect central reward systems.
143. Sugar can cause cancer of the rectum.
144. Sugar can cause endometrial cancer.
145. Sugar can cause renal (kidney) cell carcinoma.
146. Sugar can cause liver tumors.
peripheral protein 在 史丹福狂想曲 Facebook 八卦
一位年輕女士有輕微貧血,peripheral blood smear如下,診斷是甚麼?(答案如下)
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我們看到病人很多的紅血球都變成了橢圓形,她得的是遺傳性橢圓形紅細胞增多症(Hereditary elliptocytosis)。
一般病人的紅血球是雙凹形(Biconcave)的,因為這個形狀可以增加紅血球的表面積,令氧氣可以以更快的速度透過紅血球的薄膜擴散,從而增加了它運送氧氣的速度。但要維持這個奇怪的形狀其實並不容易,因為薄膜要承受的張力很大,所以要一些稱為細胞骨骼(Cytoskeleton)的特別分子去維持它的形狀。
Hereditary elliptocytosis的病人有基因缺憾,令紅血球表面的細胞骨骼,如spectrin、protein 4.1或band 3等出現問題,紅血球的薄膜就不能維持它的正常形狀,張力會令紅血球變成奇怪的橢圓形形狀。
這些紅血球比較脆弱,很容易受到滲透的影響,只要把它們放在鹽水中,水就會滲透進紅血球,令它們爆破。以往醫生就是用這個方法去檢測hereditary spherocytosis,這方法稱為osmotic fragility test。但這個測試並不準確,所以在現代已被新式的EMA binding test所取締。
症狀方面,約九成的病人都沒有嚴重症狀,但由於他們的紅血球比較脆弱,很容易受到破壞並出現溶血。溶血的病人會有貧血、黃膽等症狀,長期溶血的病人更會出現脾狀腫大及膽石等。
peripheral protein 在 Integral and Peripheral Membrane Proteins - YouTube 的八卦
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