Search
Search
蛋白激酶A(英語:Protein kinase A,簡稱為PKA)在細胞生物學中是指其活性取決於細胞環腺苷酸(cAMP)水平的一家族酶類。蛋白激酶A也被稱為環腺苷酸依賴性蛋白 ...
#2. ERK integrates PKA and PKC signaling in ... - PubMed
Protein kinases belonging to the protein kinase A (PKA), protein kinase C (PKC), and extracellular signal-related kinase (ERK) families have been identified ...
#3. PKA and PKC Modulators Affect Ion Channel Function and ...
Here, we studied the effects of protein kinase C (PKC) and cAMP-dependent protein kinase A (PKA) on glycine induced currents in HEK293 cells ...
#4. 蛋白質激酶A (PKA) 和蛋白質激酶C (PKC) 在老鼠的顆粒層細胞 ...
事實上,由GPCR所調節的蛋白質激酶A (PKA) 和蛋白質激酶C (PKC) 訊息傳遞路徑已經被證實會調控卵巢細胞例如卵巢顆粒層細胞(granulosa cells) 的增生,分化和細胞的存活 ...
#5. PKA, PKC, and AKAP localization in and around the ...
For PKA and PKC, the primary signal is generated at the plasma membrane and proceeds through intermediary G-proteins that stimulate adenylyl ...
#6. HA 100 dihydrochloride (mM/ml), MYLK, PKA, PKC and PKG ...
MW 350.26, Purity > 98%. Myosin light chain kinase, PKA, PKC and PKG inhibitor (IC50 values are 8 (PKA), 12 (PKC), 4 (PKG) and 240 μM (myosin light chain ...
#7. Targeting of PKA, PKC and protein phosphatases to cellular ...
This review summarizes recent findings relating to the concept of targeting PKA, PKC and the major serine/threonine phosphatases, PP1, PP2A and PP2B, ...
#8. PKA\PKC Inhibitor Cocktail | 20-129 - Merck Millipore
The PKA\PKC Inhibitor Cocktail controls the biological activity of PKA\PKC. This small molecule/inhibitor is primarily used for Biochemicals applications.
#9. PKA\PKC Inhibitor Cocktail - Sigma-Aldrich
The PKA\PKC Inhibitor Cocktail controls the biological activity of PKA\PKC. This small molecule/inhibitor is primarily used for Biochemicals applications.
#10. Protein kinase (PKA, PKC, AKT, GRK, AGC-related, RSK ...
Protein kinase (PKA, PKC, AKT, GRK, AGC-related, RSK, DBF2, SGK). Chapter. 503 Accesses. Part of the Springer Handbook of Enzymes book series (HDBKENZYMES ...
#11. Protein kinases inhibitor for EGFR/PKA/PKC 彙整| 卓昇有限公司
Protein kinases inhibitor for EGFR/PKA/PKC. 首頁 / 商品Short Summary / Protein kinases inhibitor for EGFR/PKA/PKC. 顯示單一結果.
#12. GSKIP+的PKA結合位和GSK3β+結合位相互影響
... A(PKA)、protein kinase B (PKB)、protein kinase C (PKC)和Wingless (Wnt ) 路徑,而激酶的特異性及功能性可藉由蛋白間的交互作用及特定的氨基酸鍵結來調控。
#13. Phosphorylation by PKC and PKA regulate the kinase ... - PNAS
Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4. Maria Castañeda-Buenoa,b,c, Juan Pablo Arroyoa ...
#14. PKC and PKA Phosphorylation Affect the Subcellular ...
PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells. Int J Med Sci 2009; 6(2):93-101. doi:10.7150/ijms.6.93.
#15. PKA\PKC Inhibitor Cocktail | 20-129 - EMD Millipore
The PKA\PKC Inhibitor Cocktail controls the biological activity of PKA\PKC. This small molecule/inhibitor is primarily used for Biochemicals applications.
#16. The Disturbance of Hippocampal CaMKII/PKA/PKC ...
In addition, aberrant changes in hippocampal protein kinase C (PKC) and protein kinase A (PKA) signaling in type 1 and type 2 diabetic rats were ...
#17. Phylogenetic analysis of the PRKX, PKA, PKC, protein kinase ...
Download scientific diagram | Phylogenetic analysis of the PRKX, PKA, PKC, protein kinase B (PKB), cGMP protein kinases, and serum-and ...
#18. The Mitogen-Activated Protein Kinase Cascade Couples PKA ...
In the present studies we observed that hippocampal MAPK activation is regulated by both the PKA and PKC systems; moreover, we found that a wide ...
#19. 050530 - TnI PKA/PKC Strain Details - The Jackson Laboratory
Common Name: TnI PKA/PKC. PKA-TnI transgenic mice express a rat troponin I, cardiac 3 (Tnni3 or TnI) gene modified to include the following ...
#20. PKA Inhibidores | SCBT - Santa Cruz Biotechnology
Nombre del producto/Solicitud NÚMERO DE... ' data‑toggle="tooltip"> H‑7 H‑7 is An inhibitor of PKA and PKC 84477‑87‑2 ' data‑toggle="tooltip"> MDL‑27,032 MDL‑27,032 is a PKA and PKC inhibitor 110124‑55‑5
#21. ERK Integrates PKA and PKC Signaling in Superficial Dorsal ...
Protein kinases belonging to the protein kinase A (PKA), protein kinase C (PKC), and extracellular signal-related kinase (ERK) families have been identified ...
#22. PKA and PKC Balance in Synapse Elimination during ... - MDPI
A detailed statistical analysis of the differences between the PKA and PKC effects in the synapse elimination could help to explore this point.
#23. A Dual Parameter FRET Probe for Measuring PKC and PKA ...
Artificial as well as physiological stimulants produced a negative or positive change in FRET efficiency following PKA or PKC activation, ...
#24. PKA,PKC和SFKs对下丘脑弓状核神经元兴奋性的调节及其机制 ...
[摘要]:目的:已有文献报道c AMP依赖性蛋白激酶(protein kinase A,PKA),蛋白激酶C(protein kinase C,PKC)和Src家族激酶(Src family kinases,SFKs)在调节神经元可塑性中 ...
#25. PKA and PKC are required for long-term but not short-term in ...
In vivo injection of PKA or PKC inhibitors blocked long-term LFI memory formation. Moreover, a persistent phase of PKA activity, although not PKC activity, was ...
#26. PKA and ERK, but not PKC, in the Amygdala Contribute to ...
Protein kinases such as PKA, PKC, and ERK, play important roles in the central ... The effects of PKA and PKC activators on spinal transmission and ...
#27. Protein kinase A (PKA) family | Enzymes
Protein kinase A (PKA) family in the IUPHAR/BPS Guide to PHARMACOLOGY. ... x.x) · AGC: Containing PKA, PKG, PKC families; Protein kinase A (PKA) family ...
#28. DaphnetinEGFR/PKA/PKC蛋白激酶抑制剂20mg
DaphnetinEGFR/PKA/PKC蛋白激酶抑制剂20mg. 产品编号:APE-N1567-20mg 品牌:APExBIO 原厂货号:N1567; 产品分类:; 应用分类: ...
#29. PKA | Inhibitors - MedChemExpress
H-89 dihydrochloride is a potent and selective inhibitor of protein kinase A (PKA) with an IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase.
#30. and Protein Kinase C-phosphorylated Glia Maturation Factor ...
fold) the catalytic activity of PKA itself, resulting in a positive feedback loop. Furthermore, GMF phosphoryl- ated by protein kinase C (PKC), ...
#31. 下丘脑弓状核神经元中PKA-PKC-Src家族激酶对放电活性的 ...
发现cAMP依赖性蛋白激酶A家族(PKA),蛋白激酶C家族(PKC)和Src家族激酶(SFK)在疼痛超敏反应中起重要作用。但是,为了理解PKA,PKC和SFK的作用 ...
#32. Targeted disruption of PKC from AKAP signaling complexes
While the A Kinase Anchoring Protein (AKAP) family of scaffold proteins universally bind PKA, several were also found to scaffold PKC, ...
#33. ox-LDL通过PKA/PKC途径上调PHF2促进THP-1巨噬细胞炎症反应
ox-LDL通过PKA/PKC途径上调PHF2促进THP-1巨噬细胞炎症反应,THP1巨噬细胞;;炎症;;血浆低密度脂蛋白;;蛋白激酶途径;;植物同源结构域指蛋白2,目的:本实验通过培养THP-1巨 ...
#34. Roles of c-Fos, EGR-1, PKA, and PKC in cognitive ... - FI-Admin
expression or activity of EGR-1, c-Fos, PKA, and PKC after propofol anesthesia. Thirty-six. Sprague-Dawley rats aged 20 months and 36 Sprague-Dawley rats ...
#35. PKC and PKA Regulate AChR Dynamics at the ... - PLOS
PKA and PKC have been extensively studied in many cell types, including muscle cells. Predominantly, two isoforms of PKC are found to be ...
#36. AKAP79, PKC, PKA and PDE4 participate in a G q -linked ...
AC2 (adenylate cyclase 2) is stimulated by activation of Gq-coupled muscarinic receptors through PKC (protein kinase C) to generate localized cAMP in HEK ...
#37. Modulation of HERG K+ Channels by Chronic Exposure to ...
This study was designed to investigate the effects of acute and chronic exposure to PKA or PKC activators and inhibitors on HERG channel ...
#38. Brand: Invitrogen PHZ1131 - Fisher Scientific
Shop Invitrogen 1 MG K252A INHIBITOR. K252A INHIBITS PKA, PKG, MLCK, PKC, CaMK, phosphorylase kinase, MAP kinase & numerous other kinases by acting as a ...
#39. Consecutive pharmacological activation of PKA and PKC ...
Cyclic AMP and PKA activity were increased in TP hearts. H-89 and sotalol blocked the cardioprotective effect of TP and TP-induced PKC activation. Isoproterenol ...
#40. A role for amygdaloid PKA and PKC in the acquisition of long ...
A role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in rats. Citation. Goosens, K. A., Holt, W., & Maren, S. (2000).
#41. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate ...
cAMP via PKA attenuates PKC-dependent ERK1/2 activation only in the presence of proAKAP4. St-HT31, which disrupts PKA-regulatory subunit II ...
#42. PKC抑制剂 - Selleck中国
GSK690693 是一种泛Akt抑制剂,靶向作用于Akt1/2/3,在无细胞试验中IC50为2 nM/13 nM/9 nM,也对AGC激酶家族:PKA,PrkX和PKC同工酶敏感。GSK690693 也能有效地抑制CAMK家族 ...
#43. PKA and CaMKII mediate PI3K activation in bovine sperm by ...
by Hofmann (2004)). In spermatozoa, PKC was found to participate in sperm capacitation, acrosome reaction, and motility (Breitbart et al. 1992, Breitbart & Naor ...
#44. Peripheral involvement of PKA and PKC in subcutaneous bee ...
The roles of central protein kinases A and C (PKA and PKC) in various pain states have intensively b.
#45. Targeting of PKA, PKC and protein phosphatases to cellular ...
and roles of the binding proteins involved in PKA, PKC and protein phosphatase targeting to cellular micro- domains. Specific attention will be given to ...
#46. Signaling by the CysLT2 Receptor: Involvement of PKA, PKC ...
Signaling by the CysLT2 Receptor: Involvement of PKA, PKC and Downstream AP-1 and NF-kB Elements in IL-8 Gene Transcription ... RATIONALE: Cysteinyl-leukotrienes ...
#47. PKA, PKC, and the protein phosphatase 2A influence HAND ...
Unlike most bHLH proteins, HAND factors exhibit promiscuous dimerization properties. We report that phosphorylation/dephosphorylation via PKA, PKC, and a ...
#48. and PKC-mediated regulatory phosphorylations of PMCA and ...
PKA and PKC activities and PKA- and PKC-mediated regulatory phosphorylations of PMCA and SERCA from vas deferens tissue.
#49. PKA - TargetMol
PKA is also known as cAMP-dependent protein kinase . Protein kinase A has several ... The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC.
#50. Time-dependent involvement of PKA/PKC in contextual ...
Time-dependent involvement of PKA/PKC in contextual memory consolidation. Behavioural brain research. 2002 Jul 18;133(133). 159-64. PMID: 12110449 [PubMed] ...
#51. C3. Protein Kinase C (PKC) and Calmodulin-Dependent ...
C3. Protein Kinase C (PKC) and Calmodulin-Dependent Kinase (CAM-PK). CC BY NC SA. Last updated: Mar 5, 2021. Save as PDF · C2. Protein Kinase A (PKA) · C4.
#52. Kinase Group AGC - WikiKinome
The AGC group is named after the protein kinase A, G, and C families (PKA, PKC, PKG) which have a long history as cytoplasmic ...
#53. PKA | Protein kinase A - Selleck Chemicals
Bisindolylmaleimide IV (Arcyriarubin A, BIM IV, Compound 5/1a) is a potent inhibitor of protein kinase C (PKC) with IC50 of 0.55 μM. Bisindolylmaleimide IV also ...
#54. PKCθ and PKA are antagonistic partners in the NF-AT ...
Abstract. We here investigate the crosstalk of PKC and PKA signaling during primary CD3+ T-lymphocyte activation using pharmacologic ...
#55. Roles of c-Fos, EGR-1, PKA, and PKC in cognitive dysfunction ...
This study aimed to investigate possible changes in the spatial memory of rats and the expression or activity of EGR-1, c-Fos, PKA, and PKC after propofol ...
#56. Regulation of Organelle Movement in Melanophores by ...
Expression of a recombinant inhibitor of protein kinase A (PKA) results in spontaneous ... We conclude that PKA and PKC activate two different pathways for ...
#57. PKA (Protein Kinase A) Colorimetric Activity Kit
The PKA Activity research-use-only kit is a colorimetric activity assay designed for the ... PKA shares substrate specificity with Akt (PKB) and PKC.
#58. 以二階隱藏式馬可夫模型預測特定蛋白激酶磷酸化的位置
... 在重要激酶PKA、PKC、CDK等現有資料集上,可分別達到82%、74% 和82% 辨識率。 ... 將有蛋白激酶註解的資料依照蛋白激酶屬性PKA、PKC、CDK 等分類建立十八個資料集 ...
#59. PKA and PKC partially rescue Long QT type 1 phenotype by ...
Our data indicates that stimulation by PKA and PKC can partially rescue LQT1 mutant channels with weakened response to PIP2 by strengthening channel ...
#60. PKA - Kinases (Serine-Threonine Specific Protein) - Products
All of these proteins contribute to the PKA signaling networks that permeate every mammalian cell. AGC kinases listed: PKA, PKC, PKD. [1] The ...
#61. Enzymes, Signaling Proteins, Extracellular Ligands, Signaling ...
PKC iota, Active ... Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases.
#62. PKA-dependent activation of PKC, p38 MAPK and IKK in ...
These actions of dBcAMP were diminished by the presence of the inhibitors of protein kinase A (PKA), protein kinase C (PKC), p38 MAPK and ...
#63. Protein Kinase A (PKA) - YouTube
Protein Kinase A ( PKA ). 52,167 views Apr 1, 2015 Donate here: http://www.aklectures.com/donate.php Website video link: ...
#64. PKA and PKC Modulators Affect Ion Channel Function and ...
Glycine receptors (GlyRs) are important mediators of fast inhibitory neurotransmission in the mammalian central nervous system.
#65. [PDF] Protein serine/threonine kinases (PKA, PKC and CaMKII ...
Activity of PKA is regulated by its direct access to cAMP. ... Protein serine/threonine kinases (PKA, PKC and CaMKII) involved in ischemic brain pathology.
#66. Noradrenaline induced PKC and PKA mediated translocation ...
Noradrenaline induced PKC and PKA mediated translocation of Na-K ATPase α1-subunit to the plasma membrane in Neuro-2a cells. Manjeet Kaur.
#67. Regulation of Cardiac L-Type Calcium Channels by Protein ...
Crosstalk between PKA and PKC pathways occurs in the modulation of ICa. ... For example, activation of protein kinase C (PKC) has resulted in widely ...
#68. PKC与PKA的信号通路分别是什么? - 答魔科研
PKC 与PKA都是通过催化多种蛋白质上Ser/Thr磷酸化,调节多种细胞的代谢、生长、增殖和分化[细胞生物学]。但是PKA为cAMP依赖性的蛋白激酶,而PKC是一 ...
#69. PKA C-α Antibody#4782 - Cell Signaling Technology
Polyclonal Antibody for studying PKA C-alpha. ... PKA shares substrate specificity with Akt (PKB) and PKC, which are characterized by an arginine at ...
#70. Protein Kinase A–Mediated Effects of Protein Kinase C Partial ...
We identified PKA activation as a mechanism of HMI-1a3–induced anticancer ... Protein kinase A (PKA) and PKC are serine/threonine kinases ...
#71. PKA調節的基因調控(PKA-mediated gene regulation)
A. 蛋白激酶A(Protein Kinase A;PKA): a. 是一種替蛋白質(受質)加上磷酸根的酵素 b. 在未活化狀態(休息)時為四聚體(tetramer)
#72. The mitogen-activated protein kinase ... - Scholars@UAB
MAPK plays a critical role in transcriptional regulation by PKC, because MAPK activation is a necessary component for increased CREB phosphorylation in response ...
#73. Effects of PKC and PKA Inhibitors on the cAMP-Stimulant ...
Intracellular application of the endogenous protein kinase A (PKA) inhibitor, protein kinase ... activation of thses two protein kinases, PKC and PKA, is.
#74. PKA Inhibitors | Biocompare
Staurosporine · Quantity: 1 mg · Formula: C28H26N4O · Purity: ≥99% (HPLC) · Target: Inquire · Family: Cancer Markers, Kinase · Subfamily: PKA, PKC.
#75. PKA和PKC的分子结构和作用机制 - 豆丁网
PKA 和PKC 的分子结构和作用机制宁波大学摘要:蛋白激酶PKA和PKC 蛋白耦联受体所介导的细胞信号通路中的重要的信号转导因子,参与多种细胞功能活动的调节,在细胞通讯中 ...
#76. Channel Inhibitory Activity via the PKC Pathway in Pulmonary ...
Furthermore, 5-HT (10 μM)-inhibited Kv1.5 protein was unaffected by the PKA inhibitor KT5720 (1 μM) and the PKC activator PMA (1 μM), but these effects were ...
#77. Protein Kinase A and Protein Kinase C Connections
Distinct roles of PKC and PKA in angiogenesis. PKC isoforms are key mediators in hormone, growth factor, and neurotransmitter-triggered pathways of cell ...
#78. A brief talk on the bioequivalence - Scientific Protocols
There are many kinds of protein kinases. This article focuses on the functions of protein kinase PKA, PKB, PKC and MAPC. There are two main functions of protein ...
#79. 蛋白激酶詳解,你該了解一下! - 每日頭條
(1)蛋白激酶A(protein kinase A,PKA)即cAMP 依賴性蛋白激酶。 ... PKC 底物非常廣泛,包括參與信號轉導的底物,如表皮生長因子受體、胰島素受 ...
#80. Protein Kinase A (PKA) - AK Lectures
Protein Kinase A (PKA) ... PKA is activated when the sympathetic nervous system kicks in and initiates the flight-or-fight ... Is there a lecture for PKC?
#81. PKA/Akt/PKC/p70 S6K キナーゼ活性測定キット
PKA /Akt/PKC/p70 S6K キナーゼ活性測定キット | 各キナーゼ活性測定キットは、非RIアッセイですので安全で短時間(4.5時間)のうちに信頼性の高い ...
#82. 蛋白激酶详解,了解一下! | 每日生物评论
(1)蛋白激酶A(protein kinase A,PKA)即cAMP 依赖性蛋白激酶。 ... PKC 底物非常广泛,包括参与信号转导的底物,如表皮生长因子受体、胰岛素受 ...
#83. 蛋白激酶A - PKA - 中文百科知識
蛋白激酶A (protein kinase A,PKA)又稱依賴於cAMP的蛋白激酶A (cyclic-AMP dependent protein ... 蛋白激酶C(protein kinase C,PKC) 是G蛋白偶聯受體系統中的效應物, ...
#84. The cyclic AMP signaling pathway: Exploring targets for ...
... including cAMP-PKA-CREB, NO-cGMP-PKG and IP3-Ca2+-PKC. ... cAMP, adenosine 3′,5′-cyclic monophosphate; PKA, protein kinase A; CRE, ...
#85. The Role of Lymphokines in the Immune Response
... ( Protein kinase Agonist ) Ligands on Nuclear Protooncogene Modulation in Synchronized , Early G , Blocked Cells GF PKC PKA GF + PKC GF + PKA PKC + PKA ...
#86. 蛋白激酶C(PKC),Protein kinase C英语短句,例句大全 - X技术
1.Protein kinase A (PKA) and protein kinase C (PKC) are potential targets in treating tumour and their over expression leads to cellular proliferation and ...
#87. Inhibitors of Protein Kinases and Protein Phosphates
Keywords PKA · PKC· PDK1 · Rho kinase· Isoquinoline · H7· H8· H89· H-1152P · HA-1077· Fasudil · Y-27632· Balanol· Staurosporine · UCN01· Bisindolylmaleimide ...
#88. Figure 1 - View Image
T2Rs: bitter taste receptors; IP3: inositol triphosphate; PKC: protein kinase C; PKA: protein kinase A; NO: nitric oxide; NOS: nitric oxide synthase; ...
#89. Introduction to Cellular Signal Transduction
... Prodynorphin CAMP PKA IRBP Binding to IRE Jun B cAMP PKA Steroid Receptor Binding to RE Receptor linked with PLC DAG PKC# Various Transcription Binding ...
#90. 蛋白激酶A_百度百科
蛋白激酶A(protein kinase A,PKA)又称依赖于cAMP的蛋白激酶A(cyclic-AMP dependent protein kinase A),是一种结构最简单、生化特性最清楚的蛋白激酶。
#91. cAMP & PKA - Biochemistry Video - Clutch Prep
cAMP & PKA ; Phosphoinositide GPCR Signaling · PSP Secondary Messengers & PKC ; 60 mins · 38 mins ; 0 completed · 0 completed ; Learn · Learn.
#92. Protein Kinase A (PKA) 信号通路
A-3 Hydrochloride是PKA(cAMP依赖性蛋白激酶,Ki =4.3μM)和cGMP依赖性蛋白激酶,Ki =3.8μM,PKC(蛋白激酶C,Ki =47μM),酪蛋白激酶I和II的抑制剂, 和MLCK(肌球 ...
#93. HTTP/1.1 200 OK Date: Sun, 24 Jul 2022 06:19:39 GMT Server
HTTP/1.1 200 OK Date: Sun, 24 Jul 2022 06:19:39 GMT Server: Apache/2.4.6 (CentOS) PHP/5.4.16 X-Powered-By: PHP/5.4.16 Connection: close ...
#94. Physiology, Biochemistry, and Pharmacology of Transporters ...
hMATE1 hMATE2K 130 120110100 9080* * 706050* 40302010 0 PKA PKC PI3K CaM p56lck CKII PKA PKC PI3K CaM p56lck CKII pathway activation (+) or + + - - - - + + ...
#95. Physiology of the Gastrointestinal Tract - 第 552 頁 - Google 圖書結果
... sodium-selective conductances L-type Jejunum/human 10–30 pS High-voltage Bay K8644, DHP PKA, PKC, Cav1.2 (M) 12, 110, 113, colon/mouse activated, ACh, ...
#96. Post-Genomic Cardiology - 第 574 頁 - Google 圖書結果
The cystic fibrosis transmembrane conductance regulator (CFTR) is Cl− channel activated by cAMPprotein kinase (PKA), protein kinase C (PKC) or ...
#97. Pharmacological Effects of Ethanol on the Nervous System
( 1994 ) demonstrated that activators of PKC produce a 227 % increase in the ... These kinases include PKA , PKC , and a protein tyrosine kinase ( Huganir ...
#98. Connexin Cell Communication Channels: Roles in the Immune ...
... 292 Proinflammatory agents, 70 Proinflammatory growth factors, 312 Protein kinase A (PKA), 162 Protein kinase C (PKC), 162 Protein kinase G (PKG), ...
pka pkc 在 Protein Kinase A (PKA) - YouTube 的八卦
Protein Kinase A ( PKA ). 52,167 views Apr 1, 2015 Donate here: http://www.aklectures.com/donate.php Website video link: ... ... <看更多>