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Ibuprofen + Acetaminophen Seems as Effective as Opioids + Acetaminophen for Acute Extremity Pain
By the Editors
Ibuprofen and opioids are similarly effective for short-term relief of acute extremity pain when combined with acetaminophen, according to a JAMA study.
Some 400 adults presenting to the emergency department with moderate-to-severe acute extremity pain (e.g., from sprain or fracture) were randomized to one of four single-dose oral treatments:
Ibuprofen (400 mg) and acetaminophen (1000 mg)
Oxycodone (5 mg) and acetaminophen (325 mg)
Hydrocodone (5 mg) and acetaminophen (300 mg)
Codeine (30 mg) and acetaminophen (300 mg)
At 2 hours, pain scores had declined in all groups, with no statistically or clinically significant differences across the groups.
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